Chemokines and inflammation in heart disease: adaptive or maladaptive?
Chemokines and inflammation in heart disease: adaptive or maladaptive?
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发表时间：
2011
影响因子：
0.1
通讯作者：
S. Tarzami
中科院分区：
文献类型：
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作者：
S. Tarzami
心脏病不仅是美国死亡、残疾和医疗费用的主要原因，也是全世界死亡的主要原因。因此，减轻缺血相关心脏损伤的治疗可能会影响广大人群，并对健康和财政产生重大影响。在动物和人类中，心脏功能障碍与循环趋化因子水平升高有关。该领域的大多数研究都集中在趋化因子表达作为梗死后炎症反应的一个突出特征。此类研究调查了趋化因子在炎症白细胞募集中的作用。关于这个主题的其他工作主要集中在干细胞治疗或因素，例如。趋化因子动员骨髓祖细胞作为改善收缩功能障碍的可能途径。大量临床前研究和几项初步临床试验的结果支持促进骨髓源性细胞募集到梗塞心脏并增加损伤后归巢的可行性，支持细胞疗法可能具有治疗潜力的观点。然而，他们没有解决自分泌/旁分泌效应的可能性，其中心肌细胞表面上存在的趋化因子受体调节对应激的功能反应，其中本质上可以是适应性的或适应不良的。
Heart disease is not only the leading cause of death, disability, and healthcare expense in the US, but also the leading cause of death worldwide. Therefore, treatments to lessen ischemia-related cardiac damage could affect a broad swath of the population and have significant health and fiscal impacts. Cardiac dysfunction has been associated with elevated circulating chemokine levels, both in animals and humans. Most studies in this area have focused on chemokine expression as a prominent feature of the post-infarction inflammatory response. Such studies have investigated the role of chemokines in inflammatory leukocyte recruitment. Other work on this topic has focused on stem-cell therapy or factors e.g. chemokines mobilizing bone marrow progenitor cells as possible avenues for improving contractile dysfunction. Findings from numerous preclinical studies and several initial clinical trials support the feasibility of promoting the recruitment of bone marrow-derived cells to the infarcted heart and increased homing following injury, supporting the notion that cell therapy might have therapeutic potential. They have not, however, addressed the possibility of an autocrine/paracrine effect wherein the chemokine receptors, present on the cardiac myocyte surface, modulate functional responses to stress in which can be adaptive or maladaptive in nature.