Neuroblastoma in a patient with Sotos' syndrome.
Neuroblastoma in a patient with Sotos' syndrome.
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DOI：
10.1136/jmg.27.2.130
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发表时间：
1990-02
影响因子：
4
通讯作者：
M. Nance;J. Neglia;Dinesh Talwar;S. Berry;Dillon M. Nance
中科院分区：
文献类型：
--
作者：
M. Nance;J. Neglia;Dinesh Talwar;S. Berry;Dillon M. Nance
索托斯综合征，或大脑发育迟缓，是一种生长调节障碍。在Sotos综合征患儿中偶尔有肿瘤的报道，但尚不确定这是否是一种巧合，或者是否与潜在的生长障碍有关。我们报告了一个15个月大的孩子患有脊髓旁神经母细胞瘤和Sotos综合征，并建议患有这种情况的儿童可能比一般人群发生肿瘤的风险更高。
Sotos' syndrome, or cerebral gigantism, is a disorder of growth regulation. Tumours have occasionally been reported in children with Sotos' syndrome, but it is uncertain whether this is a coincidence, or whether it is aetiologically related to the underlying disorder of growth. We report a 15 month old child with a paraspinal neuroblastoma and Sotos' syndrome and suggest that children with this condition may be at higher risk for developing tumours than the general population.