CYTOKINES INDUCED BY LONG-TERM POTENTIATION (LTP) RECORDING: A POTENTIAL EXPLANATION FOR THE LACK OF CORRESPONDENCE BETWEEN LEARNING/MEMORY PERFORMANCE AND LTP
CYTOKINES INDUCED BY LONG-TERM POTENTIATION (LTP) RECORDING: A POTENTIAL EXPLANATION FOR THE LACK OF CORRESPONDENCE BETWEEN LEARNING/MEMORY PERFORMANCE AND LTP
复制标题
长时程增强 (LTP) 记录诱导的细胞因子：学习/记忆表现与 LTP 之间缺乏对应关系的潜在解释
DOI：
10.1016/j.neuroscience.2012.11.010
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发表时间：
2013-02-12
期刊：
影响因子：
3.3
通讯作者：
Zhang, Y.
中科院分区：
文献类型：
--
作者：
Huang, Y.;Hu, Z.;Zhang, Y.
学习/记忆表现与长期增强（LTP）诱导之间的关系尚不明确。尽管大量数据支持学习/记忆表现与LTP之间的强烈对应关系，但许多研究也提供了相反的证据。在这项研究中，我们发现，与衰老加速小鼠/抵抗小鼠（SAMR1）相比，2个月大的衰老加速小鼠/倾向小鼠8 （SAMP8小鼠）在莫里斯水迷宫（MWM）中的表现受损，LTP增强。使用完全弗氏佐剂（CFA）刺激的BALB/c小鼠在穿梭盒测试中表现更好，但与完整动物相比，LTP受损。有趣的是，使用不完全弗氏佐剂（IFA）刺激的BALB/c小鼠比没有LTP损伤的完整小鼠表现更好。细胞因子分析显示，SAMR1和SAMP8小鼠的完整海马组织中白细胞介素-6 （IL-6）、白细胞介素-10 （IL-10）和tnf - α含量与免疫挑战的BALB/c小鼠和完整动物的海马组织中白细胞介素-6 （IL-6）、白细胞介素-10 （IL-10）和tnf - α含量无显著差异。进一步分析表明，与SAMP8和完整的BALB/c小鼠相比，SAMR1和cfa挑战动物用于LTP记录的海马组织中细胞因子含量的增加更高。相关分析显示，促炎因子IL-6和tnf - α与LTP呈负相关，抗炎因子IL-10与LTP呈正相关。这些结果表明，实验中LTP操作诱导的促炎细胞因子（例如，通过电极插入引起的组织损伤）可能是导致记忆/学习能力与LTP之间缺乏对应关系的因素之一。(c) 2012 IBRO。Elsevier Ltd.出版。版权所有。
The relationship between learning/memory performance and long-term potentiation (LTP) induction is ambiguous. Although a large body of data supports a strong correspondence between learning/memory performance and LTP, many studies have also provided evidence to the contrary. In this study, we found that 2-month-old senescence-accelerated mice/prone 8 (SAMP8 mice) displayed both impaired performance in a Morris Water Maze (MWM) and enhanced LTP compared to senescence-accelerated mice/resistance 1 (SAMR1). BALB/c mice challenged with Complete Freund's Adjuvant (CFA) performed better in the shuttle-box test but displayed impaired LTP compared to intact animals. It is interesting that BALB/c mice challenged with Incomplete Freund's Adjuvant (IFA) performed better than intact animals, with no LTP impairment. Cytokine analysis showed no significant differences between the interleukin-6 (IL-6), interleukin-10 (IL-10) or TNF-alpha content in the intact hippocampal tissues of either the SAMR1 and SAMP8 mice or the immune-challenged BALB/c and intact animals. Further analysis demonstrated that the increase in cytokine content was higher in the hippocampal tissues used for LTP recording in the SAMR1 and CFA-challenged animals compared to the SAMP8 and intact BALB/c mice. A correlation analysis demonstrated that pro-inflammatory cytokines (IL-6 and TNF-alpha) displayed a negative correlation with LTP, while an anti-inflammatory cytokine (IL-10) displayed a positive correlation with LTP. These results suggest that pro-inflammatory cytokines induced by LTP manipulation in experiments (e.g., via tissue injury caused by electrode insertion) may be one of the factors contributing to the observed lack of correspondence between memory/learning ability and LTP. (c) 2012 IBRO. Published by Elsevier Ltd. All rights reserved.