Facile bubble-assisted evaporation-induced assembly of high-density arrays of Co3O4 nano/microlotus leaves: fluorescent properties, drug delivery, and biocompatibility
Facile bubble-assisted evaporation-induced assembly of high-density arrays of Co3O4 nano/microlotus leaves: fluorescent properties, drug delivery, and biocompatibility
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气泡辅助蒸发诱导高密度 Co3O4 纳米/微荷叶阵列的组装：荧光特性、药物输送和生物相容性
DOI：
10.1039/c3ce42149j
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发表时间：
2014-02
期刊：
影响因子：
3.1
通讯作者：
Huichen Guo
中科院分区：
文献类型：
--
作者：
Guoxiu Tong;Fangting Liu;Wenhua Wu;Chaoli Tong;Ru Qiao;Huichen Guo
采用气泡辅助蒸发诱导法制备了具有良好荧光性能和生物相容性的高密度Co 3 O 4纳/微米荷叶阵列，并对其在药物释放方面的潜在应用进行了评估。通过蒸发六水合硝酸钴的丙酮溶液，利用反应体系中原位产生的气泡引导晶体涂层和/或晶核的组装，实现了Co 3 O 4纳/微米荷叶阵列的形貌控制生长。采用场发射扫描电子显微镜（FE-SEM）、X射线能谱（EDX）、X射线衍射（XRD）、X射线光电子能谱（XPS）、透射电子显微镜（TEM）、氮气吸附/脱附和比表面积（BET）等测试手段对纳米/微米荷叶阵列进行了表征。加载到这些纳米/微米荷叶阵列中的异硫氰酸荧光素（FITC）被用作模型平台以评估阵列作为药物递送工具的功效。其释放动力学研究揭示了纳米/微米荷叶阵列中FITC的两步释放模式超过24小时，在几小时内爆发释放约83.4%的染料。我们设想，这些Co 3 O 4纳米/微米荷叶阵列，具有分层多孔结构和高效率的吸附化学品，如荧光染料FITC，可以作为一个交付车辆控制释放的化学品管理到活细胞，打开这些阵列的潜力，包括药物储存和释放以及细胞的代谢操纵的各种应用。
High-density arrays of Co3O4 nano/microlotus leaves with excellent fluorescent properties and biocompatibility were synthesized using a facile bubble-assisted evaporation-induced approach and its potential application in drug delivery was assessed. The morphologically controlled growth of Co3O4 nano/microlotus leaf arrays could be realized by evaporating the acetone solution of cobalt nitrate hexahydrate in a tunable kinetic procedure, in which the gas bubbles generated in situ in the reaction system directed the assembly of the crystal coatings and/or the nuclei. These nano/microlotus leaf arrays were characterized by field-emission scanning electron microscopy (FE-SEM), X-ray energy dispersive spectroscopy (EDX), X-ray diffraction (XRD), X-ray photoelectron spectroscopy (XPS), transmission electron microscopy (TEM), nitrogen adsorption/desorption and Brunauer–Emmett–Teller (BET) measurements. Fluorescein isothiocyanate (FITC) loaded into these nano/microlotus leaf arrays was used as a model platform to assess the efficacy of the arrays as a drug delivery tool. Its release kinetics study revealed a two-step release pattern of FITC from the nano/microlotus leaf arrays for over 24 h, with a burst release of around 83.4% of the dye just within a few hours. We envision that these Co3O4 nano/microlotus leaf arrays, with the hierarchically porous structures and high efficacy to adsorb chemicals such as the fluorescent dye FITC, could serve as a delivery vehicle for controlled release of chemicals administered into live cells, opening the potential of these arrays for a diverse range of applications including drug storage and release as well as metabolic manipulation of cells.
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影响因子：
29.4
作者：
Ting Yu;Yanwu Zhu;X. J. Xu;Zexiang Shen;Ping-Ou Chen;Chwee Teck Lim;J. Thong;C. Sow
通讯作者：
Ting Yu;Yanwu Zhu;X. J. Xu;Zexiang Shen;Ping-Ou Chen;Chwee Teck Lim;J. Thong;C. Sow
影响因子：
3.3
作者：
A. Patel;Fanxin Wu;J. Zhang;C. L. Torres-Martínez;R. Mehra;A. Y. Yang;S. Risbud
通讯作者：
A. Patel;Fanxin Wu;J. Zhang;C. L. Torres-Martínez;R. Mehra;A. Y. Yang;S. Risbud
影响因子：
19
作者：
Guoxiu Tong;Jianguo Guan;Qingjie Zhang
通讯作者：
Guoxiu Tong;Jianguo Guan;Qingjie Zhang
DOI：
10.1021/la803768y
发表时间：
2009-01
期刊：
Langmuir : the ACS journal of surfaces and colloids
影响因子：
--
作者：
J. Ye;P. Van Dorpe;W. Van Roy;G. Borghs;G. Maes
通讯作者：
J. Ye;P. Van Dorpe;W. Van Roy;G. Borghs;G. Maes
影响因子：
3.7
作者：
VANELP, J;WIELAND, JL;TURNER, TS
通讯作者：
TURNER, TS