SUPPRESSOR MUTATION IN NEMATODE ACTING ON SPECIFIC ALLELES OF MANY GENES
SUPPRESSOR MUTATION IN NEMATODE ACTING ON SPECIFIC ALLELES OF MANY GENES
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DOI：
10.1038/275715a0
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发表时间：
1978-01-01
期刊：
影响因子：
64.8
通讯作者：
BRENNER, S
中科院分区：
文献类型：
--
作者：
WATERSTON, RH;BRENNER, S
通过对肌肉缺陷突变体的回复分析，在秀丽隐杆线虫中分离出抑制突变。抑制突变作用于至少 6 个基因的特定等位基因，在一种情况下，它部分地恢复了突变体的功能基因产物，否则该突变体将缺乏该产物。抑制器的这些和其他特征表明它在信息传递的某个步骤发挥作用，可能通过类似于微生物中描述的机制。
A suppressor mutation was isolated in Caenorhabditis elegans through reversion analysis of a muscle-defective mutant. The suppressor mutation acts on specific alleles of at least 6 genes and in 1 case it partially restores functional gene product to a mutant otherwise lacking that product. These and other features of the suppressor suggest that it acts at some step in information transfer, perhaps through mechanisms similar to those described in microorganisms.