Role of microRNAs in premature ovarian insufficiency.
Role of microRNAs in premature ovarian insufficiency.
复制标题
microRNA 在卵巢早衰中的作用
DOI：
10.1186/s12958-017-0256-3
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发表时间：
2017-05-12
期刊：
影响因子：
--
通讯作者：
Lai D
中科院分区：
文献类型：
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作者：
Guo Y;Sun J;Lai D
卵巢功能不全（POI）是一种典型的闭经疾病，持续至少4个月。40岁以下女性的典型特征包括雌激素水平下降和血清促卵泡激素（FSH）浓度升高，主要由医源性因素、核型异常和遗传因素引起。然而，在大约90%的病例中，POI的病因仍然未知。POI可能导致不孕、骨质疏松、心血管疾病和认知功能障碍。MicroRNAs （miRNAs）是一类内源性非编码rna (ncRNAs)，可以介导参与增殖、分化、凋亡、发育、肿瘤发生和造血调控的基因的翻译后沉默。近年来，mirna在POI发展中的调控功能一直是人们研究的热点。本文综述了miRNA的机制基因（Dicer、Drosha和xpo5）与POI的关系以及POI患者血浆中miRNA的表达谱。此外，还研究了与POI相关的几种特定mirna (miR-23a, miR-27a, miR-22-3p, miR-146a, miR-196a, miR-290-295， miR-423和miR-608)，以突出值得进一步研究的问题。深入了解mirna的确切调控作用对于获得特发性POI病因学的新见解和提供该领域新的研究方向至关重要。
Premature ovarian insufficiency (POI) is a typical disorder of amenorrhea lasting for a minimum of 4 months. The typical characteristics comprised of declined estrogen and raised serum concentrations of follicle-stimulating hormone (FSH) in women <40-year-old, primarily originating from iatrogenic factors, karyotypic abnormalities, and genetic factors. However, the etiology of POI remains unknown in approximately 90% of cases. POI could lead to infertility, osteoporosis, cardiovascular disorder, and cognitive dysfunction. MicroRNAs (miRNAs) are a class of endogenous noncoding RNAs (ncRNAs) that can mediate post-translational silencing of the genes involved in the regulation of proliferation, differentiation, apoptosis, development, tumorigenesis, and hematopoiesis. Recently, the regulatory functions of miRNAs in the development of POI have been the topic of intensive research. The present review addresses the association of miRNAs’ machinery genes (Dicer,Drosha, andXPO5) with POI and the miRNA expression profiles in the plasma of patients with POI. In addition, several specific miRNAs (miR-23a, miR-27a, miR-22-3p, miR-146a, miR-196a, miR-290-295, miR-423, and miR-608) related to POI are also examined in order to highlight the issues that deserve further investigation. A thorough understanding of the exact regulatory roles of miRNAs is imperative to gain novel insights into the etiology of idiopathic POI and offer new research directions in the field.