Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability
Conjugation of curcumin with PVP capped gold nanoparticles for improving bioavailability
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DOI：
10.1016/j.msec.2012.07.022
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发表时间：
2012-12-01
影响因子：
7.9
通讯作者：
Datar, Suwarna
中科院分区：
文献类型：
--
作者：
Gangwar, Rajesh K.;Dhumale, Vinayak A.;Datar, Suwarna
姜黄素是一种天然多酚化合物，具有惊人的治疗应用前景，但由于其在水中的溶解性较差，缺乏生物利用度。聚乙烯吡咯烷酮(PVP)是一种公认的药物载体，可用于促进姜黄素与金纳米粒子的偶联，改善姜黄素在水中的溶解度。FTIR和UV-Vis光谱分析表明，在这种共轭化合物中，姜黄素的二芳基庚烷类发色基团保持不变，这是生物医学应用中急需的基团。这项工作显示了这种结合物在生物医学领域作为治疗和成像材料的良好前景。(C)2012爱思唯尔B.V.保留所有权利。
Curcumin, a natural polyphenolic compound, has astounding therapeutic applications but lacks in bioavailability mainly due to its poor solubility in water. Polyvinyl pyrrolidone (PVP) which is a proven drug carrier has been used to facilitate the conjugation of curcumin with gold nanoparticles and to improve the solubility of curcumin in water. In this conjugate diaryl heptanoid chromophore group of curcumin which is a much needed group in biomedical applications remains intact as observed from FTIR and UV-vis spectroscopy analysis. The work shows good promise for such conjugates as therapeutic-cum-imaging materials in biomedical field. (C) 2012 Elsevier B.V. All rights reserved.