NEURAL SUBSTRATES FOR TONE-CONDITIONED BRADYCARDIA DEMONSTRATED WITH 2-DEOXYGLUCOSE .2. AUDITORY-CORTEX PLASTICITY
NEURAL SUBSTRATES FOR TONE-CONDITIONED BRADYCARDIA DEMONSTRATED WITH 2-DEOXYGLUCOSE .2. AUDITORY-CORTEX PLASTICITY
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DOI：
10.1016/0166-4328(86)90228-7
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发表时间：
1986-06-01
影响因子：
2.7
通讯作者：
SCHEICH, H
中科院分区：
文献类型：
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作者：
GONZALEZLIMA, F;SCHEICH, H
采用2-脱氧葡萄糖（2-DG）方法，对条件反射过程中和条件反射后听皮层（AC）的代谢活动进行了定位。使用单独的动物组，比较了配对和非配对的4-5 kHz FM音（CS）和中脑网状刺激（US）的效果，以进行获取、消退和敏化训练。大鼠心脏减速条件调频音显示模式的AC代谢活动明显不同于对照组动物。2-DG标记的tonotopic模式包括两个连续的纺锤形带对应的神经元的位置在4-5 kHz带宽的最佳频率响应。网状刺激单独或与音调相结合产生了广泛的增加2-DG摄取。至少有两种类型的调制效应似乎与音调模式相互作用。第一个涉及选择性增强CS-US效应会聚的AC区域中的诱发活动。这种效应可能与学习有关，因为它仅限于条件反射组。第二个影响涉及的背景吸收的2-DG在AC的普遍增加。这种效应可能与网状敏化有关，因为这是所有接受网状刺激的组所共有的。本研究结果是第一次解剖学证明的调制效果的听觉学习AC代谢活动。
The 2-deoxyglucose (2-DG) method was used to map the metabolic activity of the auditory cortex (AC) during and after conditioning. Using separate groups of animals, the effects of both paired and unpaired presentations of a 4–5 kHz FM tone (CS) and midbrain reticular stimulation (US) were compared for acquisition, extinction and sensitization training. Rats with cardiac deceleration conditioned to the FM tone showed a pattern of AC metabolic activity distinctly different from that seen in control animals. The tonotopic pattern of 2-DG labeling consisted of two contiguous spindle-shaped bands corresponding to the location of neurons with best frequency response in the 4–5 kHz band width. Reticular stimulation alone or combined with the tones produced a widespread increase of 2-DG uptake. At least two types of modulatory effects appeared to interact with the tonotopic pattern. The first involved a selective enhancement of evoked activity in the AC region of convergence of CS-US effects. This effect may be related to learning because it was restricted to the conditioning group. The second effect involved a general increase in background uptake of 2-DG in AC. This effect may be related to reticular sensitization because it was common to all groups subjected to reticular stimulation. The present findings are the first anatomical demonstration of the modulatory effects of auditory learning on AC metabolic activity.