The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk
The XPD variant alleles are associated with increased aromatic DNA adduct level and lung cancer risk
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DOI：
10.1093/carcin/23.4.599
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发表时间：
2002-04-01
期刊：
影响因子：
4.7
通讯作者：
Hemminki, K
中科院分区：
文献类型：
--
作者：
Hou, SM;Fält, S;Hemminki, K
DNA 修复蛋白着色性干皮病互补组 D (XPD) 参与许多烟草和环境致癌物诱导的 DNA 损伤的核苷酸切除修复。为了研究 XPD 外显子 10（G > A，Asp312Asn）和外显子 23（A > C，Lys751Gln）常见多态性的功能影响，我们对 185 名瑞典肺癌病例（97 名吸烟者和 88 名从不吸烟者）和 162 名匹配的人群对照（83 名吸烟者和 79 名从不吸烟者）进行了基因分型。仅在从不吸烟者中，尤其是年轻人中，一或两个变异等位基因的存在与肺癌风险增加相关。
The DNA repair protein xeroderma pigmentosum complementation group D (XPD) is involved in the nucleotide excision repair of DNA lesions induced by many tobacco and environmental carcinogens. In order to study the functional impact of the common polymorphisms in XPD exon 10 (G > A, Asp312Asn) and exon 23 (A > C, Lys751Gln), we have genotyped 185 Swedish lung cancer cases (97 smokers and 88 never-smokers) and 162 matched population controls (83 smokers and 79 never-smokers). Presence of one or two variant alleles was associated with increased risk for lung cancer among never-smokers only, in particular younger (