Effect of an extract from evening-primrose seeds on postprandial blood glucose level and its active components
Effect of an extract from evening-primrose seeds on postprandial blood glucose level and its active components
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DOI：
10.3136/nskkk.50.180
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发表时间：
2003-01-01
期刊：
影响因子：
0.2
通讯作者：
Konishi, Y
中科院分区：
文献类型：
--
作者：
Aitani, M;Kimura, H;Konishi, Y
以月见草(Oenthera biennis L.)种子为原料制备乙醇提取物。在这项研究中，我们研究了EPE对餐后血糖水平及其活性成分的影响。EPE中检出的多酚成分为：没食子酸2.7%，没食子酸3.1%，(+)-儿茶素3.4%，原花青素B1和原花青素B3 1.5%。原花青素(PAC)占总花青素的41.4%。然后，我们在体外检测了EPE的这些成分对α-葡萄糖苷酶的抑制作用，并利用大鼠餐后血糖水平检测了这些成分对α-葡萄糖苷酶的抑制作用。结果提示：1)EPE对α-葡萄糖苷酶活性的抑制是其抑制餐后高血糖的原因；2)PAC是EPE的主要活性成分。
An ethanol extract (EPE) was prepared from defatted seeds of Evening-prim rose (Oenothera biennis L.). In this study, we examined the effect of EPE on postprandial blood glucose level and its active components. Detected polyphenol components of EPE were penta-O-galloyl-beta-D-glucose (PGG) 2.7%, gallic acid 3.1%, (+) -catechin 3.4%, procyanidin B1 and procyanidin B3 1.5%. 41.4% of the total proanthocyanidin (PAC) was contained in EPE. Then, we examined the effect of these components of EPE on inhibitory action against alpha-glucosidase in vitro and on the postprandial blood glucose level using rats. The results suggested that 1) the suppression of postprandial hyperglycemia was caused by inhibition of alpha-glucosidase activity due to EPE, 2) PAC was the main active component of EPE.