Regulation of the germinal center response by microRNA-155
Regulation of the germinal center response by microRNA-155
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DOI：
10.1126/science.1141229
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发表时间：
2007-04-27
期刊：
影响因子：
56.9
通讯作者：
Rajewsky, Klaus
中科院分区：
文献类型：
--
作者：
Thai, To-Ha;Calado, Dinis Pedro;Rajewsky, Klaus
microRNA是在多个水平上参与生物控制的小RNA种类。使用基因缺失和转基因方法，我们表明，进化保守的microRNA-155（miR-155）在哺乳动物免疫系统中具有重要作用，特别是在调节T辅助细胞分化和生发中心反应，以产生最佳的T细胞依赖性抗体反应。miR-155至少部分地通过调节细胞因子的产生来发挥这种控制作用。这些结果还表明，单个microRNA可以对哺乳动物体内分化过程发挥关键控制作用。
MicroRNAs are small RNA species involved in biological control at multiple levels. Using genetic deletion and transgenic approaches, we show that the evolutionarily conserved microRNA-155 (miR-155) has an important role in the mammalian immune system, specifically in regulating T helper cell differentiation and the germinal center reaction to produce an optimal T cell-dependent antibody response. miR-155 exerts this control, at least in part, by regulating cytokine production. These results also suggest that individual microRNAs can exert critical control over mammalian differentiation processes in vivo.