Whispering gallery mode carousel - a photonic mechanism for enhanced nanoparticle detection in biosensing
Whispering gallery mode carousel - a photonic mechanism for enhanced nanoparticle detection in biosensing
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DOI：
10.1364/oe.17.006230
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发表时间：
2009-04-13
期刊：
影响因子：
3.8
通讯作者：
Vollmer, F.
中科院分区：
文献类型：
--
作者：
Arnold, S.;Keng, D.;Vollmer, F.
观察到水溶液中的单个纳米颗粒被吸引到回音壁模式微传感器的渐逝感测环内并在其内轨道运行，仅具有微瓦的驱动功率。这种由吸引力的光学梯度力、界面相互作用和循环动量通量引起的Carbohydrate陷阱显著提高了传输到感测区域的速率，从而克服了扩散对这种小面积检测器造成的限制。共振频率的波动，所造成的径向布朗运动的纳米粒子，揭示了径向捕获的潜力和纳米粒子的大小。由于吸引力在表面将颗粒吸引到最高的倏逝强度，因此发现结合步骤是均匀的。(C)2009年美国光学学会
Individual nanoparticles in aqueous solution are observed to be attracted to and orbit within the evanescent sensing ring of a Whispering Gallery Mode micro-sensor with only microwatts of driving power. This Carousel trap, caused by attractive optical gradient forces, interfacial interactions, and the circulating momentum flux, considerably enhances the rate of transport to the sensing region, thereby overcoming limitations posed by diffusion on such small area detectors. Resonance frequency fluctuations, caused by the radial Brownian motion of the nanoparticle, reveal the radial trapping potential and the nanoparticle size. Since the attractive forces draw particles to the highest evanescent intensity at the surface, binding steps are found to be uniform. (C) 2009 Optical Society of America