Moderators and mediators of treatment outcome for youth with ADHD: Understanding for whom and how interventions work
Moderators and mediators of treatment outcome for youth with ADHD: Understanding for whom and how interventions work
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DOI：
10.1016/j.ambp.2006.04.012
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发表时间：
2007-01-01
期刊：
影响因子：
--
通讯作者：
Hinshaw, Stephen P.
中科院分区：
文献类型：
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作者：
Hinshaw, Stephen P.
客观。-介绍ADHD儿童多模式治疗研究（MTA）中治疗反应的调节剂和介质的数据。调节变量（定义具有较大或较小干预反应的亚组的基线因素）和中介变量（解释干预如何“工作”的治疗期间发生的因素）被描述为具体应用于MTA研究的结果。关键调节变量（共病焦虑症，公共援助，注意缺陷/多动障碍的严重程度，父母抑郁症，智商）和中介过程（消极/无效的父母纪律）进行了审查。未来的治疗研究应该明确考虑对调节变量和中介变量的探索，这可以极大地帮助临床试验的解释力，并为干预研究指明关键的下一步。
Objective.-To present data on moderators and mediators of treatment response from the Multimodal Treatment Study of Children With ADHD (MTA).Methods.-Moderator variables (baseline factors that define subgroups with greater vs lesser intervention response) and mediator variables (factors occurring during treatment that explain how interventions "work") are described with specific application to the outcomes of the MTA Study.Results.-Key moderator variables (comorbid anxiety disorder, public assistance, severity of attention-deficit/hyperactivity disorder, parental depressive symptomatology, IQ) and mediator processes (negative/ineffective parental discipline) are reviewed.Conclusions.-Treatment research in the future should explicitly consider the exploration of moderator and mediator variables, which can greatly aid the explanatory power of clinical trials and specify the critical next steps for intervention research.