Melatonin induction of gonadal quiescence in pinealectomized Syrian hamsters.
Melatonin induction of gonadal quiescence in pinealectomized Syrian hamsters.
复制标题
褪黑素诱导松果体切除的叙利亚仓鼠性腺静止。
DOI：
10.1126/science.563102
复制
发表时间：
1977
期刊：
影响因子：
56.9
通讯作者：
B. Goldman
中科院分区：
文献类型：
--
作者：
L. Tamarkin;C. Hollister;N. Lefebvre;B. Goldman
Pinealectomized Syrian hamsters were injected thrice daily with 25 micrograms of melatonin per injection. The injections were administered at 3-hour intervals either during the day or during the night of a photoperiodic cycle of 14 hours of light and 10 hours of darkness. After 6 weeks of treatment with melatonin during the night, both pinealectomized and intact hamsters had reduced testis weight, and pinealectomized hamsters showed decreased levels of serum gonadotropins. Injection of melatonin during the day for 7 weeks either once (75 micrograms) a day or thrice (25 micrograms per injection) daily caused a reduction in testis weight in pinealectomized hamsters. Both pinealectomized and intact females injected with melatonin thrice daily during the day became anovulatory by week 7 of treatment. These results are similar to those observed when hamsters are exposed to a short photoperiod, suggesting that melatonin may be acting as a hormone in mediating the effects of photoperiod on the reproductive system of the Syrian hamster.
