PAIN MECHANISMS - A NEW THEORY
PAIN MECHANISMS - A NEW THEORY
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DOI：
10.1126/science.150.3699.971
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发表时间：
1965-01-01
期刊：
影响因子：
56.9
通讯作者：
WALL, PD
中科院分区：
文献类型：
--
作者：
MELZACK, R;WALL, PD
自世纪之交以来，疼痛的本质一直是激烈争论的主题。目前有两种对立的疼痛理论：（i）特异性理论，认为疼痛是一种特定的形式，如视觉或听觉，“具有自己的中枢和外周器官”（2），（ii）模式理论，认为疼痛的神经冲动模式是由非特异性受体的强烈刺激产生的，因为“没有特定的纤维，也没有特定的末梢”（3）。这两种理论都源自于冯·弗雷（von Frey）（4）和戈德谢德（Goldscheider）（5）在1894年提出的早期概念，历史上它们被认为是相互排斥的。由于我们在此的目的是提出一个关于疼痛机制的新理论，我们将在一开始就阐明我们同意和不同意特异性和模式理论的地方。
The nature of pain has been the subject of bitter controversy since the turn of the'century (1). There are currently two opposing theories of pain:(i) specificity theory, which holds that pain is a specific modality like vision or hearing," with its own central and peripheral apparatus"(2), and (ii) pattern theory, which maintains that the nerve impulse pattern for pain is produced by intense stimulation of nonspecific receptors since" there are no specific fibers and no specific endings"(3). Both theories derive from earlier concepts proposed by von Frey (4) and Goldscheider (5) in 1894, and historically they are held to be mutually exclusive. Since it is our purpose here to propose a new theory, of pain mechanisms, we shall state eXiplicitly at the outset where we agree and disagree with specificity and pattern theories.