Kidney Function and Subclinical Arrhythmias: The Multi-Ethnic Study of Atherosclerosis.
Kidney Function and Subclinical Arrhythmias: The Multi-Ethnic Study of Atherosclerosis.
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DOI：
10.1016/j.xkme.2021.06.010
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发表时间：
2021-11
期刊：
影响因子：
3.9
通讯作者：
Heckbert SR
中科院分区：
文献类型：
--
作者：
Wiggins KL;Floyd JS;Bansal N;Kestenbaum B;Heckbert SR
Patients with chronic kidney disease (CKD) are at high risk for atrial fibrillation (AF), an arrhythmia associated with progression to kidney failure and increased risk for cardiovascular complications and death, 1, 2, 3 and ventricular arrhythmias, which contribute to the increased risk for sudden cardiac death. 4 Arrhythmias are often asymptomatic and not detected clinically; thus, the true incidence and prevalence among patients with CKD are unknown. Extended ambulatory cardiac monitoring is a sensitive and unbiased method for detecting both atrial and ventricular arrhythmias, allowing accurate estimation of arrhythmia burden. The aim of this study was to investigate the presence of cardiac monitor–detected arrhythmias and their cross-sectional associations with measures of kidney function in the setting of a community-based prospective cohort study.In the Multi-Ethnic Study of Atherosclerosis (MESA), kidney function was assessed at the 2016 to 2018 study visit using 2 measures: glomerular filtration rate, estimated (eGFR) using the 2009 CKD Epidemiology Collaboration creatinine equation, 5 and urinary albumin-creatinine ratio (UACR), which was log 2 transformed for analysis. At the same visit, extended ambulatory cardiac monitoring was conducted for up to two 14-day periods per participant using the Zio Patch XT (iRhythm Technologies, Inc). 6 Device information was consolidated for participants with 2 devices. Seven arrhythmia outcomes were studied: presence of subclinical AF or atrial flutter lasting more than 30 seconds (in those with no history of clinically recognized AF/flutter), presence of monitor-detected AF/flutter (> 30 seconds), frequency of premature atrial contractions, frequency of runs of 4 or more beats of supraventricular tachycardia (SVT), frequency of premature ventricular contractions, presence of runs of 4 or more beats of ventricular tachycardia (VT), and frequency of runs of VT. Continuous outcome variables were natural log transformed. Analyses used logistic regression for binary outcomes and linear regression for continuous outcomes, adjusted for demographic and clinical risk factors. Participants who completed at least 24 hours of monitoring, had no paced rhythm, and did not receive renal replacement therapy were included in this analysis. Further details of the study methods are available in the supplementary methods (Item S1).
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影响因子：
1.3
作者：
Heckbert, Susan R.;Austin, Thomas R.;Kronmal, Richard A.
通讯作者：
Kronmal, Richard A.
DOI：
10.2215/cjn.09420818
发表时间：
2019-04-05
影响因子：
9.8
作者：
Akoum, Nazem;Zelnick, Leila R.;Bansal, Nisha
通讯作者：
Bansal, Nisha
影响因子：
6.1
作者：
Marcos, Ernaldo G.;Geelhoed, Bastiaan;Rienstra, Michiel
通讯作者：
Rienstra, Michiel
影响因子：
37.8
作者：
Alonso A;Lopez FL;Matsushita K;Loehr LR;Agarwal SK;Chen LY;Soliman EZ;Astor BC;Coresh J
通讯作者：
Coresh J
影响因子：
39.2
作者：
Levey AS;Stevens LA;Schmid CH;Zhang YL;Castro AF 3rd;Feldman HI;Kusek JW;Eggers P;Van Lente F;Greene T;Coresh J;CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)
通讯作者：
CKD-EPI (Chronic Kidney Disease Epidemiology Collaboration)