Central injection of angiotensin II alters catecholamine activity in rat brain.
Central injection of angiotensin II alters catecholamine activity in rat brain.
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中央注射血管紧张素 II 会改变大鼠脑中儿茶酚胺的活性。
DOI：
10.1152/ajpregu.1983.244.2.r257
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发表时间：
1983
期刊：
影响因子：
--
通讯作者：
Phillips,MI
中科院分区：
文献类型：
--
作者：
Sumners,C;Phillips,MI
中枢注射血管紧张素II(Ang II)会产生升压反应。本实验观察了侧脑室注射血管紧张素转换酶II对大鼠特定脑区儿茶酚胺利用的影响。加压剂量的血管紧张素Ⅱ刺激蓝斑、中缝大核和脑干AI区以及下丘脑去甲肾上腺素(NE)的利用。NE利用率的这些增加是选择性的，相同地区的多巴胺利用率没有改变。此外，NE利用率的变化是直接的，而不是由于Ang II引起的血压升高，因为静脉注射高渗盐水引起的类似升压效应不会改变上述任何区域的NE利用率。脑室注射Ang II后，终板穹隆下器和血管器官等同时含有儿茶酚胺和Ang II受体的区域并未显示儿茶酚胺利用的实质性变化。本研究表明，脑室注射Ang II可以激活特定的脑NE富集区。其中一些区域与已知的血压控制中心相关，并与参与中枢Ang II升压反应的脑儿茶酚胺能区有关。
Centrally injected angiotensin II (ANG II) produces a pressor response. The effect of ANG II injected intracerebroventricularly on catecholamine utilization in specific rat brain regions was examined. A pressor dose of ANG II stimulated an increase in norepinephrine (NE) utilization in the locus coeruleus, raphe magnus and AI regions of the brain stem, and in the hypothalamus. These increases in NE utilization were selective, and dopamine utilization was not altered in the same regions. Also, the changes in NE utilization were direct and not due to the rise in blood pressure caused by ANG II, since a similar pressor effect caused by intravenously injected hypertonic saline did not alter NE utilization in any of the above regions. Areas such as the subfornical organ and organum vasculosum of the lamina terminalis that contain both catecholamines and ANG II receptors did not show a substantial change in catecholamine utilization after intracerebroventricularly injected ANG II. This study demonstrates that specific brain NE rich regions are activated by intracerebroventricular injection of ANG II. Some of these regions correlate with known blood pressure control centers and the data points to brain catecholaminergic regions which are involved in the central ANG II pressor response.