Regulation of aging and age-related disease by DAF-16 and heat-shock factor
Regulation of aging and age-related disease by DAF-16 and heat-shock factor
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DOI：
10.1126/science.1083701
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发表时间：
2003-05-16
期刊：
影响因子：
56.9
通讯作者：
Kenyon, C
中科院分区：
文献类型：
--
作者：
Hsu, AL;Murphy, CT;Kenyon, C
The Caenorhabditis elegans transcription factor HSF-1, which regulates the heat-shock response, also influences aging. Reducing hsf-1 activity accelerates tissue aging and shortens life-span, and we show that hsf-1 overexpression extends life-span. We find that HSF-1, like the transcription factor DAF-16, is required for daf-2-insulin/IGF-1 receptor mutations to extend life-span. Our findings suggest this is because HSF-1 and DAF-16 together activate expression of specific genes, including genes encoding small heat-shock proteins, which in turn promote longevity. The small heat-shock proteins also delay the onset of polyglutamine-expansion protein aggregation, suggesting that these proteins couple the normal aging process to this type of age-related disease.
