Bone marrow graft rejection as a function of antibody-directed natural killer cells.
Bone marrow graft rejection as a function of antibody-directed natural killer cells.
复制标题
骨髓移植排斥是抗体导向的自然杀伤细胞的功能。
DOI：
10.1084/jem.161.3.563
复制
发表时间：
1985
期刊：
影响因子：
--
通讯作者：
Dennert,G
中科院分区：
文献类型：
--
作者：
Warner,JF;Dennert,G
There is conclusive evidence that acute bone marrow transplant rejection in lethally irradiated mice is caused by natural killer (NK) cells. The rejection of marrow allografts is exquisitely specific and is controlled by antigenic determinants encoded in or near the H-2 gene complex. The specificity of in vivo marrow graft rejection contrasts with the in vitro specificity pattern of NK cells in cytotoxicity assays. We therefore examined how NK cells cause H-2-specific marrow graft rejection in vivo. Several experimental approaches are presented that suggest that natural antibody, present in responder strains of mice, specifically directs NK cells in an antibody-dependent cytolytic and/or cytostatic reaction, resulting in marrow graft rejection. The following evidence for this mechanism is documented. The ability to reject a marrow graft can be passively transferred by serum from responder to allogeneic nonresponder mice and the specificity of rejection can be mapped within the H-2 region. Serum-induced marrow graft rejection is abrogated following depletion of immunoglobulin, and the serum of responder mice is able to induce a specific antibody-dependent cytotoxic reaction in vitro.
