2,4-dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines.
2,4-dinitrobenzenesulfonamides: A simple and practical method for the preparation of a variety of secondary amines and diamines.
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DOI：
10.1016/s0040-4039(97)01334-8
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发表时间：
1997-08-18
影响因子：
1.8
通讯作者：
Kan, T
中科院分区：
文献类型：
--
作者：
Fukuyama, T;Cheung, M;Kan, T
由伯胺和2，4-二硝基苯磺酰氯容易地制备的2，4-二硝基苯磺酰胺可以通过Mitsunobu反应或通过常规方法烷基化以优异的产率得到N，N-二取代的磺酰胺。由于2，4-二硝基苯磺酰胺可以在不脱保护的情况下除去，因此通过组合使用这些保护/活化基团可以制备多种二胺。(C)1997 Elsevier Science Ltd.
2,4-Dinitrobenzenesulfonamides, readily prepared from primary amines and 2,4-dinitrobenzenesulfonyl chloride,can be alkylated by the Mitsunobu reaction or by the conventional methods to give N,N-disubstituted sulfonamides in excellent yields Since 2,4-dinitrobenzenesulfonamides can be removed without deprotecting 2-nitrobenzenesulfonamides, a wide variety of diamines could be prepared by the combined use of these protecting/activating groups. (C) 1997 Elsevier Science Ltd.