Non-rapid eye movement sleep and wake neurophysiology in schizophrenia.
Non-rapid eye movement sleep and wake neurophysiology in schizophrenia.
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DOI：
10.7554/elife.76211
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发表时间：
2022-05-17
期刊：
影响因子：
7.7
通讯作者：
Peyrache, Adrien
中科院分区：
文献类型：
--
作者：
Kozhemiako, Nataliia;Wang, Jun;Jiang, Chenguang;Wang, Lei A.;Gai, Guanchen;Zou, Kai;Wang, Zhe;Yu, Xiaoman;Zhou, Lin;Li, Shen;Guo, Zhenglin;Law, Robert;Coleman, James;Mylonas, Dimitrios;Shen, Lu;Wang, Guoqiang;Tan, Shuping;Qin, Shengying;Huang, Hailiang;Murphy, Michael;Stickgold, Robert;Manoach, Dara;Zhou, Zhenhe;Zhu, Wei;Hal, Mei-Hua;Purcell, Shaun M.;Pan, Jen Q.;Peyrache, Adrien
受客观神经生理学标记物对严重精神疾病患者丘脑皮质功能的潜在影响，我们全面描述了多个领域的关键非快速眼动（NREM）睡眠参数，它们的相互依赖性，以及它们与清醒事件相关电位和症状严重程度的关系。在72名精神分裂症（SCZ）患者和58名对照组中，我们证实了SCZ睡眠纺锤体密度的显着降低，并扩展了这些发现，表明快和慢纺锤体特性在很大程度上不相关。我们还描述了一种新的措施，慢振荡和纺锤体的相互作用，在SCZ衰减。主要的睡眠结果在人口统计学上不同的样本中重复，并且基于多个NREM成分的联合模型在统计学上预测了重复队列中的疾病状态。虽然也改变了患者，听觉事件相关电位唤醒时引起的NREM指标无关。与越来越多的文献表明SCZ中丘脑皮质功能障碍一致，我们的表征确定了独立的NREM和唤醒EEG生物标志物，这些生物标志物可能指示SCZ病理生理学的不同方面，并指向疾病异质性的多种神经机制。这项研究为单独或组合评估这些神经生理学标志物奠定了基础，以指导治疗和预防工作，并确定最有可能从特定干预措施中受益的个体。
Motivated by the potential of objective neurophysiological markers to index thalamocortical function in patients with severe psychiatric illnesses, we comprehensively characterized key non-rapid eye movement (NREM) sleep parameters across multiple domains, their interdependencies, and their relationship to waking event-related potentials and symptom severity. In 72 schizophrenia (SCZ) patients and 58 controls, we confirmed a marked reduction in sleep spindle density in SCZ and extended these findings to show that fast and slow spindle properties were largely uncorrelated. We also describe a novel measure of slow oscillation and spindle interaction that was attenuated in SCZ. The main sleep findings were replicated in a demographically distinct sample, and a joint model, based on multiple NREM components, statistically predicted disease status in the replication cohort. Although also altered in patients, auditory event-related potentials elicited during wake were unrelated to NREM metrics. Consistent with a growing literature implicating thalamocortical dysfunction in SCZ, our characterization identifies independent NREM and wake EEG biomarkers that may index distinct aspects of SCZ pathophysiology and point to multiple neural mechanisms underlying disease heterogeneity. This study lays the groundwork for evaluating these neurophysiological markers, individually or in combination, to guide efforts at treatment and prevention as well as identifying individuals most likely to benefit from specific interventions.