Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani
Inhibition of CD1 expression in human dendritic cells during intracellular infection with Leishmania donovani
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DOI：
10.1128/iai.72.1.589-592.2004
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发表时间：
2004-01-01
影响因子：
3.1
通讯作者：
Porcelli, SA
中科院分区：
文献类型：
--
作者：
Amprey, JL;Späth, GF;Porcelli, SA
Dendritic cells can initiate antimicrobial responses by CD1-mediated presentation of pathogen-derived glycolipids. We show that the protozoan Leishmania donovani inhibits CD1 expression and prevents activation of CD1-restricted T cells by dendritic cells. Evasion of presentation by CD1 may represent a Leishmania survival strategy to avoid recognition of abundant parasite glycolipids.
