Development od an implantable flexible probe for simultaneous near-infrared spectroscopy and electrocorticography.
Development od an implantable flexible probe for simultaneous near-infrared spectroscopy and electrocorticography.
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开发用于同步近红外光谱和皮层电图描记的植入式柔性探针。
DOI：
10.1109/tbme.2013.2279888
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发表时间：
2014
期刊：
影响因子：
--
通讯作者：
M. Niwayama
中科院分区：
文献类型：
--
作者：
T. Yamakawa;T. Inoue;Y. He;M. Fujii;M. Suzuki;M. Niwayama
近红外光谱（NIRS）和皮层电图（ECoG）的组合从不同方面提供了关于皮层活动的有益信息。将这种多模式测量能力集成到单个装置中并在慢性硬膜下植入期间直接测量皮质活动可能是临床诊断和神经科学的有力手段。然而，基于光纤的近红外光谱探针不能被小型化以植入大脑中，并且ECoG电极在近红外光谱测量中的光散射效应是未知的。我们在这里描述了一个灵活的探头，小到足以慢性硬膜下植入，同时NIRS和ECoG的发展。两个不同波长的发光二极管和两个光电二极管安装在聚酰亚胺基柔性基板上，ECoG电极的形成采用了最小化NIRS记录中伪影的设计。制造的探针测量ECoGs在足够的空间分辨率和亚微摩尔的血红蛋白浓度的变化，在体内实验与急性植入到大鼠。不同的源-检测器距离的血红蛋白浓度的测量变化的比较揭示了测量值的可靠性和模拟模型的实用性。所提出的颅内多模态探头可以为神经外科手术前和手术中评估提供有益的证据，并以高空间分辨率揭示电生理学和血流动力学的相互作用，而不会因头皮血流而产生伪影。
A combination of near-infrared spectroscopy (NIRS) and electrocorticography (ECoG) provides beneficial information on cortical activity from different aspects. Integration of such multimodal measurement capability into a single apparatus and the direct measurement of cortical activity during chronic subdural implantation may be a powerful means for clinical diagnosis and neuroscience. However, an optical fiber-based NIRS probe cannot be miniaturized for implantation into the brain, and the light-scattering effect of ECoG electrodes in NIRS measurements is unknown. We describe here the development of a flexible probe, small enough for chronic subdural implantation, for simultaneous NIRS and ECoG. Two light-emitting diodes of different wavelengths and two photodiodes were mounted on a polyimide-based flexible substrate, and ECoG electrodes were formed with a design minimizing artifacts in NIRS recording. The fabricated probe measured ECoGs at sufficient spatial resolution and submicromolar changes in hemoglobin concentrations in in vivo experiments with acute implantation into a rat. Comparison of measured changes in hemoglobin concentrations for different source–detector distances reveals the reliability of the measured values and the practicality of the simulation model. The proposed intracranial multimodality probe may provide beneficial evidence for pre- and intrasurgical assessment of neurosurgery and reveal the interaction of electrophysiology and hemodynamics at high spatial resolution without artifacts due to scalp blood flow.