Distinct neuroanatomical bases of episodic and semantic memory performance in Alzheimer's disease
Distinct neuroanatomical bases of episodic and semantic memory performance in Alzheimer's disease
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DOI：
10.1016/j.neuropsychologia.2013.01.013
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发表时间：
2013-04-01
期刊：
影响因子：
2.6
通讯作者：
Taylor, Kirsten I.
中科院分区：
文献类型：
--
作者：
Hirni, Daniela I.;Kivisaari, Sasa L.;Taylor, Kirsten I.
阿尔茨海默病(AD)的神经原纤维病变始于内侧周边皮质(MPRC)，然后扩散到内侧颞叶前叶(AMTL)的内嗅皮层(ERC)和海马区(HP)。虽然ERC/HP复合体在情景记忆形成中的作用是公认的，但最近的研究表明，PRC需要形成对个别物体的语义记忆。我们的目的是在健康的成熟个体和极早期的AD患者中，测试常用的情景记忆和语义记忆的临床测量是否分别与ERC/HP和MPRC完整性显著相关。130例正常对照组，32例遗忘性轻度认知障碍患者，其中部分患者处于AD的早期(即临床前期)，10例早期AD患者接受了神经心理测试和高分辨率解剖及弥散磁共振成像。基于体素的回归分析测试了情节记忆(加州言语学习和Rey Osterrieth复杂图形测试的延迟回忆分数)和语义记忆(波士顿命名测试，类别流畅性)表现与灰质(GM)感兴趣区域和全脑分数各向异性(FA)体素值相关的区域。当控制相反的记忆表现时，较差的情节记忆表现与双侧ERC/HP GM体积和相关脑白质完整性减少有关，但与MPRC GM体积无关。较差的语义记忆表现与左侧MPRC和ERC/HP GM体积减少以及导致PRC的白质束FA值减少有关。这些结果表明了aMTL内部的部分分工，并表明如果情景记忆表现得到控制，极早期AD的MPRC损伤可能可以通过常见的语义记忆临床测试来检测到。(C)2013爱思唯尔有限公司。保留所有权利。
Alzheimer's disease (AD) neurofibrillary pathology begins in the medial perirhinal cortex (mPRC) before spreading to the entorhinal cortex (ERC) and hippocampus (HP) in anterior medial temporal lobe (aMTL). While the role of the ERC/HP complex in episodic memory formation is well-established, recent research suggests that the PRC is required to form semantic memories of individual objects. We aimed to test whether commonly used clinical measures of episodic and semantic memory are distinctly associated with ERC/HP and mPRC integrity, respectively, in healthy mature individuals and very early AD patients. One hundred thirty normal controls, 32 amnestic mild cognitive impairment patients, some of whom are in the earliest (i.e., preclinical) stages of AD, and ten early-stage AD patients received neuropsychological testing and high-resolution anatomic and diffusion MRI. Voxel-based regression analyses tested for regions where episodic memory (delayed recall scores on the California Verbal Learning and Rey Osterrieth Complex Figure Tests) and semantic memory (Boston Naming Test, category fluency) performance correlated with gray matter (GM) regions of interest and whole-brain fractional anisotropy (FA) voxel values. When controlling for the opposing memory performance, poorer episodic memory performance was associated with reduced bilateral ERC/HP GM volume and related white matter integrity, but not with mPRC GM volume. Poor semantic memory performance was associated with both reduced left mPRC and ERC/HP GM volume, as well as reduced FA values in white matter tracts leading to the PRC. These results indicate a partial division of labor within the aMTL and suggest that mPRC damage in very early AD may be detectable with common clinical tests of semantic memory if episodic memory performance is controlled. (C) 2013 Elsevier Ltd. All rights reserved.