IRON STATUS IN DANISH WOMEN AGED 35-65 YEARS - RELATION TO MENSTRUATION AND METHOD OF CONTRACEPTION
IRON STATUS IN DANISH WOMEN AGED 35-65 YEARS - RELATION TO MENSTRUATION AND METHOD OF CONTRACEPTION
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DOI：
10.3109/00016349309021150
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发表时间：
1993-11-01
影响因子：
4.3
通讯作者：
GRAUDAL, N
中科院分区：
文献类型：
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作者：
MILMAN, N;ROSDAHL, N;GRAUDAL, N
在一项包括883名年龄分别为35、45、55和65岁的丹麦非妊娠妇女的人口调查中，用血清铁蛋白和血红蛋白(Hb)来评估铁的状况。绝经前妇女血清S铁蛋白水平低于绝经后妇女(P<0.0001)。绝经前妇女血清铁蛋白水平中位数为42µg/L，低于绝经后妇女血清铁蛋白水平中位数80µg/L(P<0.05)。在绝经前妇女中，12.1%的人S铁蛋白低于或等于20杯/L(即铁库耗尽)，35.6%的人S铁蛋白低于或等于20杯/L(即小型铁库)。绝经后女性的相应数字分别为0.5%和13.2%。绝经前献血者(n=88)血清S铁蛋白水平低于非献血者(p<；0.001)。在绝经前妇女中，S铁蛋白水平强烈依赖于月经出血的持续时间(p<；0.0001)，而月经出血的持续时间又与避孕方法有关。使用激素避孕药(避孕药)的妇女(n=)的月经出血持续时间比不使用避孕药或宫内节育器(宫内节育器)的妇女(n=511)的月经出血时间短。服用避孕药者S-铁蛋白中位数为62杯/L，未使用避孕药或宫内节育器者为42杯/L，放置宫内节育器者为36杯/L。S-铁蛋白测定值和40杯/L(即小而耗尽的铁储备)分别在25%、48%和61%的避孕药使用者和61%的宫内节育器使用者中出现。绝经前妇女的Hb平均值为134+/-10(SD)g/L(8.3+/-0.6 mm o l/l)，中位数为132 g/L(8.2 mm o l/L)，略低于绝经后妇女的平均值137+/-10 g/L(8.5±0.6 mm o l/L)，中位数135g/L(8.4 m ol/L)(p<；0.001)。缺铁性贫血(S-铁蛋白小于或等于20µg/L和Hb<；121 g/L)在绝经前为3.0%，绝经后妇女为零。
Iron status was assessed by serum (S-) ferritin and hemoglobin (Hb) in a population survey comprising 883 non-gravid Danish women in age cohorts of 35, 45, 55, and 65 years. Premenopausal women (n = 676) had lower S-ferritin, median 42 mug/l, than postmenopausal women (n = 207), median 80 mug/l (p < 0.0001). Of premenopausal women, 12.1% had S-ferritin less-than-or-equal-to 20 mug/l (i.e. depleted iron stores), and 35.6% S-ferritin of 21-40 mug/l (i.e. small iron stores). Corresponding figures in postmenopausal women were 0.5% and 13.2%. Premenopausal blood donors (n = 88) had lower S-ferritin than non-donors (p < 0.001). In premenopausal women, S-ferritin levels were strongly dependent on the duration of menstrual bleeding (p < 0.0001), which in turn was related to the method of contraception. Women (n = 64) using hormonal contraceptives (the pill) had menstrual bleeding of shorter duration than those (n = 511) not using pills or intrauterine devices (IUD), who in turn had bleeding of shorter duration than those (n = 101) using IUD. Median S-ferritin in pill users was 62 mug/l, in those not using pills or IUD 42 mug/l, and in IUD users 36 mug/l. S-ferritin values < 40 mug/l (i.e. small and depleted iron stores) were seen in 25% of pill users, in 48% of those not using pills or IUD, and in 61% of IUD users. Hb values in premenopausal women were mean 134 +/- 10 (SD) g/l (8.3 +/- 0.6 mmol/1), median 132 g/l (8.2 mmol/l), being slightly lower than in postmenopausal women, mean 137 +/- 10 g/l (8.5 +/- 0.6 mmol/l), median 135 g/l (8.4 mmol/l) (p < 0.001). Iron deficiency anemia (i.e. S-ferritin less-than-or-equal-to 20 mug/l and Hb < 121 g/l) was found in 3.0% of premenopausal and in none of postmenopausal women.