The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects
The effect of porosity and mechanical property of a synthetic polymer scaffold on repair of osteochondral defects
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DOI：
10.1007/s00264-008-0532-0
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发表时间：
2009-06-01
影响因子：
2.7
通讯作者：
Kurosaka, Masahiro
中科院分区：
文献类型：
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作者：
Ikeda, Risa;Fujioka, Hiroyuki;Kurosaka, Masahiro
我们制备了三种类型的聚（DL-丙交酯-共-乙交酯）（PLG）支架（孔隙率：支架I 80 +/-0.9%，II 85 +/-0.8%，III 92 +/- 0.7%;用10%应变测定的压缩模量：支架I 0.26 MPa，II 0.091 MPa，III 0.0047 MPa）。用这些支架材料处理兔股骨髁骨软骨缺损，并从组织学上研究软骨修复的可能性。术后6周和12周，支架II和III组的组织学评分显著高于支架I组。具有比支架I更高孔隙率的支架II和III允许骨髓细胞更好的迁移，并且比支架I更好地用骨和软骨替换支架。这项研究表明，更高的孔隙率允许骨髓细胞迁移到支架是重要的修复骨软骨缺损。
We have made three types of poly (DL-lactide-co-glycolide) (PLG) scaffolds (porosity: scaffold I 80 +/- 0.9%, II 85 +/- 0.8%, III 92 +/- 0.7%; compression module determined with 10% strain: scaffold I 0.26 MPa, II 0.091 MPa, III 0.0047 MPa). Osteochondral defects made in the femoral condyle of rabbits were treated with these scaffolds and the possibilities of cartilage repair were investigated histologically. At post-operative weeks 6 and 12, histological scores in the groups of scaffolds II and III were significantly higher than the score in the group of scaffold I. Scaffolds II and III, which have higher porosity than scaffold I, allow better migration of bone marrow cells and better replacement of the scaffold with bone and cartilage than scaffold I. This study suggests that higher porosity allowing bone marrow cells to migrate to the scaffold is important in repairing osteochondral defects.