Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association.
Mitochondrial Dysfunction and Heart Disease: Critical Appraisal of an Overlooked Association.
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DOI：
10.3390/ijms22020614
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发表时间：
2021-01-09
影响因子：
5.6
通讯作者：
Ghinassi B
中科院分区：
文献类型：
--
作者：
Bisaccia G;Ricci F;Gallina S;Di Baldassarre A;Ghinassi B
心肌是体内最消耗能量的组织之一，每天在线粒体内燃烧6至30公斤的ATP，线粒体是心肌细胞的所谓动力室。虽然线粒体遗传性疾病占心肌病的一小部分，但线粒体功能障碍通常涉及广泛的心脏病，并且它通过产生和维持线粒体应激和能量饥饿的适应不良回路而与心力衰竭的发展有关。在这篇从实验室到临床的综述中，我们的目的是（i）描述心肌线粒体的关键功能，包括它们在缺血/再灌注损伤和细胞内钙稳态中的作用;（ii）检查线粒体功能障碍对多种心脏疾病表型及其向心力衰竭转变的贡献;和（iii）讨论靶向线粒体功能治疗心力衰竭的基本原理和现有证据，包括通过钠-葡萄糖协同转运蛋白2抑制剂。
The myocardium is among the most energy-consuming tissues in the body, burning from 6 to 30 kg of ATP per day within the mitochondria, the so-called powerhouse of the cardiomyocyte. Although mitochondrial genetic disorders account for a small portion of cardiomyopathies, mitochondrial dysfunction is commonly involved in a broad spectrum of heart diseases, and it has been implicated in the development of heart failure via maladaptive circuits producing and perpetuating mitochondrial stress and energy starvation. In this bench-to-bedside review, we aimed to (i) describe the key functions of the mitochondria within the myocardium, including their role in ischemia/reperfusion injury and intracellular calcium homeostasis; (ii) examine the contribution of mitochondrial dysfunction to multiple cardiac disease phenotypes and their transition to heart failure; and (iii) discuss the rationale and current evidence for targeting mitochondrial function for the treatment of heart failure, including via sodium-glucose cotransporter 2 inhibitors.
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影响因子：
5
作者：
Bugger H;Riehle C;Jaishy B;Wende AR;Tuinei J;Chen D;Soto J;Pires KM;Boudina S;Theobald HA;Luptak I;Wayment B;Wang X;Litwin SE;Weimer BC;Abel ED
通讯作者：
Abel ED
影响因子：
5.6
作者：
Bouitbir, Jamal;Panajatovic, Miljenko Valentin;Kraehenbuehl, Stephan
通讯作者：
Kraehenbuehl, Stephan
影响因子：
64.5
作者：
de Cabo R;Carmona-Gutierrez D;Bernier M;Hall MN;Madeo F
通讯作者：
Madeo F
影响因子：
18.2
作者：
Bowen, T. Scott;Rolim, Natale P. L.;Adams, Volker
通讯作者：
Adams, Volker
影响因子：
3.2
作者：
D'Andrea, Gabriele;Brisdelli, Fabrizia;Bozzi, Argante
通讯作者：
Bozzi, Argante