Natural cis-solamin is a mixture of two tetra-epimeric diastereoisomers:: biosynthetic implications for Annonaceous acetogenins
Natural cis-solamin is a mixture of two tetra-epimeric diastereoisomers:: biosynthetic implications for Annonaceous acetogenins
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DOI：
10.1039/b601943a
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发表时间：
2006-01-01
影响因子：
3.2
通讯作者：
Brown, RCD
中科院分区：
文献类型：
--
作者：
Hu, YL;Cecil, ARL;Brown, RCD
抗肿瘤天然产物顺式茄素已被证明以两种四差向异构体非对映异构体1A和1B的混合物存在，而茄素（6）被分离为单一非对映异构体; 1A/B和6的生物合成可能分别涉及双-环氧化物乙酸配基抗diepomuricanin A2和顺式diepomuricanin A1的酶介导的环化水合，其中水的加入区域选择性地发生在C15或C20。
The anti-tumour natural product cis-solamin has been shown to occur as a mixture two of tetra-epimeric diastereoisomers 1A and 1B, whereas solamin ( 6) was isolated as a single diastereoisomer; the biosyntheses of 1A/B and 6 are likely to involve enzyme-mediated cyclohydrations of the bis-epoxide acetogenins anti-diepomuricanin A2 and syn-diepomuricanin A1 respectively, where addition of water occurs regioselectively at either C15 or C20.