The role of atoh1 in mucous cell metaplasia.
The role of atoh1 in mucous cell metaplasia.
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DOI：
10.1155/2012/438609
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发表时间：
2012
影响因子：
--
通讯作者：
Lin J
中科院分区：
文献类型：
--
作者：
Nakamura Y;Hamajima Y;Komori M;Yokota M;Suzuki M;Lin J
中耳炎的一个关键问题是粘膜细胞化生，这是导致粘液分泌过多和疾病持续的原因。然而，对中耳炎粘膜细胞化生的分子机制知之甚少。大量关于肠上皮稳态的研究表明，碱性螺旋-环-螺旋（bHLH）转录因子Atoh1在肠杯状细胞分化中起着至关重要的作用。另一方面，作为“Ets”转录因子家族的一员，sam指向结构域的Ets转录因子（SPDEF）已被报道可引发肺部感染性疾病或哮喘的粘膜细胞化生。最近的研究证实了这些因素之间的关系，即Spdef作用于Atoh1的下游。我们可以利用这些发现来研究中耳炎，因为中耳上皮和肺上皮属于同一呼吸道。Atoh1和SPDEF可能是临床上经常被认为是“难治性”的黏液细胞化生相关中耳炎的治疗靶点。
A key issue in otitis media is mucous cell metaplasia which is responsible for mucous hypersecretion and persistence of the disease. However, little is known about the molecular mechanisms of mucous cell metaplasia in otitis media. Numerous studies of intestinal epithelial homeostasis have shown that Atonal homolog 1 (Atoh1), a basic helix-loop-helix (bHLH) transcription factor, is essential for the intestinal goblet cell differentiation. On the other hand, SAM-pointed domain-containing Ets transcription factor (SPDEF), a member of the “Ets” transcription factor family, has been reported to trigger the mucous cell metaplasia of pulmonary infectious diseases or athsma. Recent studies have demonstrated the relation of these factors, that is, Spdef functions downstream of Atoh1. We could take the adventages of these findings for the study of otitis media because both middle ear and pulmonary epithelia belong to the same respiratory tract. Atoh1 and SPDEF could be the therapeutic targets for otitis media associated with mucous cell metaplasia which is frequently considered “intractable” in the clinical settings.