FoxA1 as a lineage-specific oncogene in luminal type breast cancer
FoxA1 as a lineage-specific oncogene in luminal type breast cancer
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DOI：
10.1016/j.bbrc.2007.11.064
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发表时间：
2008-01-25
影响因子：
3.1
通讯作者：
Watanabe, Shinya
中科院分区：
文献类型：
--
作者：
Yamaguchi, Noritaka;Ito, Emi;Watanabe, Shinya
叉头转录因子FoxA1被认为参与了乳腺肿瘤的发生。然而，FoxA1在乳腺癌发展中的确切作用是有争议的。我们检测了foxa1在35种人乳腺癌细胞系中的表达，并将其与乳腺癌预后不良标志物ErbB2的表达进行了比较。我们发现FoxA1在所有erbb2阳性细胞系和一部分erbb2阴性细胞系中都有高水平表达。通过RNA干扰下调FoxA1可显著抑制erbb2阴性和FoxA1阳性乳腺癌细胞株的增殖。FoxA1的下调也通过诱导凋亡增强了赫赛汀对erbb2阳性细胞株的毒性作用。结合先前关于FoxA1是乳腺管腔细胞标志物的数据，我们目前的研究结果表明FoxA1作为一种谱系特异性癌基因在乳腺管腔细胞衍生的癌细胞增殖中起着重要作用。(c) 2007爱思唯尔公司版权所有。
The forkhead transcription factor FoxA1 is thought to be involved in mammary tumorigenesis. However, the precise role of FoxA1 in breast cancer development is controversial. We examined expression of FoxA I in 35 human breast cancer cell lines and compared it with that of ErbB2, a marker of poor prognosis in breast cancer. We found that FoxA1 is expressed at high levels in all ErbB2-positive cell lines and a subset of ErbB2-negative cell lines. Down-regulation of FoxA1 by RNA interference significantly suppressed proliferation of ErbB2-negative and FoxA1-positive breast cancer cell lines. Down-regulation of FoxA1 also enhanced the toxic effect of Herceptin on ErbB2-positive cell lines through induction of apoptosis. Taken together with previous data that FoxA1 is a marker of luminal cells in mammary gland, our present results suggest that FoxA1 plays an important role as a lineage-specific oncogene in proliferation of cancer cells derived from mammary luminal cells. (c) 2007 Elsevier Inc. All rights reserved.