Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius
Anthelmintic efficacy of cinnamaldehyde and cinnamic acid from cortex cinnamon essential oil against Dactylogyrus intermedius
复制标题
肉桂精油肉桂醛和肉桂酸对中间指环虫的驱虫效果
DOI：
10.1017/s0031182015001031
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发表时间：
2015-12-01
期刊：
影响因子：
2.4
通讯作者：
Wang, Gaoxue
中科院分区：
文献类型：
--
作者：
Ling, Fei;Jiang, Chao;Wang, Gaoxue
由于农药抗药性的发展以及对化学残留和环境污染的担忧，许多国家往往限制使用化学农药防治单殖吸虫病。因此，已经探索了使用来自植物的抗寄生虫剂作为控制单殖吸虫感染的可能方式。研究了肉桂提取物对金鱼中间指环虫的体内抑制作用。利用核磁共振和电喷雾质谱鉴定了肉桂醛和肉桂酸两种生物活性化合物。48 h的半数有效浓度（EC_（50））分别为：中间体的平均浓度分别为0.57和6.32 mg L-1。在48 h急性毒性试验中，肉桂醛和肉桂酸对金鱼的LD 50分别为13·34和59·66 mg L−1。这些数据证实肉桂醛对D.中间体，肉桂醛表现出开发候选抗寄生虫剂的潜力。
SUMMARY Utilization of chemical pesticide to control monogenean diseases is often restricted in many countries due to the development of pesticide resistance and concerns of chemical residues and environmental contamination. Thus, the use of antiparasitic agents from plants has been explored as a possible way for controlling monogenean infections. Extracts from Cinnamomum cassia were investigated under in vivo conditions against Dactylogyrus intermedius in goldfish. The two bioactive compounds, cinnamaldehyde and cinnamic acid, were identified using nuclear magnetic resonance and electrospray ionization mass spectrometry. The 48 h median effective concentrations (EC50) for these compounds against D. intermedius were 0·57 and 6·32 mg L−1, respectively. The LD50 of cinnamaldehyde and cinnamic acid were 13·34 and 59·66 mg L−1 to goldfish in 48 h acute toxicity tests, respectively. These data confirm that cinnamaldehyde is effective against D. intermedius, and the cinnamaldehyde exhibits potential for the development of a candidate antiparasitic agent.