The Controversial C5a Receptor C5aR2: Its Role in Health and Disease
The Controversial C5a Receptor C5aR2: Its Role in Health and Disease
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有争议的 C5a 受体 C5aR2：其在健康和疾病中的作用
DOI：
10.1155/2017/8193932
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发表时间：
2017-06
影响因子：
4.1
通讯作者：
Li Ke
中科院分区：
文献类型：
--
作者：
Zhang Ting;Garstka Malgorzata A.;Li Ke
在发现C5a受体C5aR1之后，C5aR2是发现的第二种结合C5a及其脱精氨酸形式的受体。作为一种七螺旋G蛋白偶联受体，但缺乏细胞内Gα信号，C5aR2是特殊和令人困惑的。自C5aR2被发现以来，关于它的分支和争议一直存在争议，从假定的配体和细胞定位到细胞内信号以及在炎症和免疫中的病理作用。C5aR2在各种疾病的动物模型中的无规则甚至相互冲突的促炎或抗炎作用使人感到困惑。本文综述了C5aR2的研究进展，试图澄清这四个有争议的方面的现有证据，并描述了C5aR2的功能。它还总结了C5aR2研究的可用工具箱。
After the discovery of the C5a receptor C5aR1, C5aR2 is the second receptor found to bind C5a and its des‐arginine form. As a heptahelical G protein‐coupled receptor but devoid of the intracellular Gαsignal, C5aR2 is special and confusing. Ramifications and controversies about C5aR2 are under debate since its identification, from putative ligands and cellular localization to intracellular signals and pathological roles in inflammation and immunity. The ruleless and even conflicting pro‐ or anti‐inflammatory role of C5aR2 in animal models of diverse diseases makes one bewildered. This review summarizes reports on C5aR2, tries to clear up available evidence on these four controversial aspects, and delineates C5aR2 function(s). It also summarizes available toolboxes for C5aR2 study.
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影响因子：
4.4
作者：
Craig Gerard;Lu Bao;O. Orozco;M. Pearson;D. Kunz;Norma P. Gerard
通讯作者：
Craig Gerard;Lu Bao;O. Orozco;M. Pearson;D. Kunz;Norma P. Gerard
影响因子：
2
作者：
R. Dmochowski
通讯作者：
R. Dmochowski
影响因子：
5.5
作者：
Jia, Nan;Semba, Umeko;Yamamoto, Tetsuro
通讯作者：
Yamamoto, Tetsuro
DOI：
10.1074/jbc.m609178200
发表时间：
2007-02-09
期刊：
The Journal of biological chemistry
影响因子：
--
作者：
Scola AM;Higginbottom A;Partridge LJ;Reid RC;Woodruff T;Taylor SM;Fairlie DP;Monk PN
通讯作者：
Monk PN