Life-time exposure to dichlorvos affects behaviour of mature rats
Life-time exposure to dichlorvos affects behaviour of mature rats
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终生接触敌敌畏会影响成年大鼠的行为
DOI：
10.1177/096032719501400904
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发表时间：
1995
影响因子：
2.8
通讯作者：
I. Dési
中科院分区：
文献类型：
--
作者：
H. Schulz;L. Nagymajtényi;I. Dési
Wistar大鼠暴露于敌敌畏[CAS编号62737]。剂量为1/25；1/50;1/75;1/100 LD50 = 3.88；1.94;1.46;和0.97 mg kg-1 DDVP，分别在整个妊娠期（gd1 -分娩）和哺乳期间通过口服给药，然后在其余生命中通过相同剂量的灌胃。研究人员在野外、多重t型迷宫和“新奇诱导梳理”测试中对这些幼崽进行了测试，以评估它们成年后的行为能力。在9-11周龄为期3周的研究中，在前2周观察到迷宫中跑步时间和错误选择的剂量相关增加。9-12周龄时，水平活动增加，垂直活动减少，排便减少；这些变化同样与剂量有关。12周大时，睡眠也会受到影响。牺牲时大脑和血液中的乙酰胆碱酯酶活性约为对照组的40%至65%，这再次反映了给药剂量。DDVP处理后大鼠行为特征的显著改变可作为判断中枢神经系统功能损伤的有用生物标志物。
Wistar rats were exposed to dichlorvos [CAS number 62737]. Doses were 1/25; 1/50; 1/75; and 1/100 LD50, that is 3.88; 1.94; 1.46; and 0.97 mg kg-1 DDVP, respectively, throughout gestation (GD1-birth) and during suckling via oral dosing to the dams, and then via the same doses by gavage for the rest of their lives. The offspring were tested in an open field (OF), a multiple T-maze, and in a 'novelty-induced- grooming' test to assess behavioural competence as adults. Dose-related increases in running time and incorrect choices in the maze were observed during the first 2 weeks of a 3-week study at 9-11 weeks of age. Horizontal activity was increased, vertical activity decreased, and defecation decreased in the OF at 9-12 weeks of age; these changes were again dose-related. Sleep was also affected at 12 weeks of age. AChE activity in the brain and in blood at sacrifice was roughly 40% to 65% of control, again reflect ing the doses administered. The significantly changed behavioural profile of DDVP treated rats may serve as a useful biomarker to judge functional damage of CNS prop erties.
脑突触膜 N-甲基-D-天冬氨酸受体有机磷酸酯相互作用的表征。
影响因子：
3.6
作者：
Johnson,PS;Michaelis,EK
通讯作者：
Michaelis,EK
三种大鼠品系毒蕈碱和多巴胺受体的比较研究。
影响因子：
5
作者：
Lim,DK;Ito,Y;Hoskins,B;Rockhold,RW;Ho,IK
通讯作者：
Ho,IK