Androgens and the molecular epidemiology of prostate cancer
Androgens and the molecular epidemiology of prostate cancer
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DOI：
10.1097/med.0b013e3282febcf6
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发表时间：
2008-06-01
影响因子：
3.2
通讯作者：
Hsing, Ann W.
中科院分区：
文献类型：
--
作者：
Chu, Lisa W.;Reichardt, Juergen K. V.;Hsing, Ann W.
综述目的尽管临床和实验证据表明雄激素在前列腺癌发生中很重要，但血清雄激素的流行病学研究尚未得出结论。在这篇综述中，我们总结了文献的现状，并为雄激素和前列腺癌的流行病学研究提供了见解和方向。最新发现迄今为止，前列腺癌血清雄激素的数据仍然没有定论。对某些雄激素代谢基因 [SRD5A2、CYP17A1 和羟基类固醇脱氢酶 (HSD) 17B1] 变异的大型研究并未显示出与前列腺癌的令人信服的联系，尽管没有足够的数据来得出与雄激素代谢相关的其他基因的结论，包括 UDP 糖基转移酶 (UGT)、磺基转移酶 (SULT)、CYP3A 和雌激素相关基因基因。有一些证据（尽管存在争议）表明，某些变异可能会给某些前列腺癌亚型带来风险。 2007 年最引人注目的发现是染色体 8q24 风险区域与前列腺癌易感性之间高度可重复的联系。 总结 除了 8q24 区域与前列腺癌风险之间的联系之外，人群研究并没有令人信服地表明雄激素代谢基因的多态性与前列腺癌风险相关。需要具有全面基因覆盖和可靠暴露数据的大型流行病学研究，以进一步阐明雄激素及其相关基因在前列腺癌中的作用。
Purpose of review Despite clinical and experimental evidence that show androgens are important in prostate carcinogenesis, epidemiologic studies of serum androgens have been inconclusive. In this review, we summarize the current state of the literature and provide insights and direction for epidemiologic research on androgens and prostate cancer.Recent findings To date, data on serum androgens in prostate cancer remain inconclusive. Large studies on variants in some androgen-metabolizing genes [SRD5A2, CYP17A1, and hydroxysteroid dehydrogenase (HSD) 17B1] do not show a convincing links to prostate cancer, though there are insufficient data to draw conclusions on other genes related to androgen metabolism, including UDP-glycosyltransferases (UGT), sulfotransferases (SULT), CYP3A, and estrogen-related genes. There is some evidence, although controversial, suggesting that select variants may confer risk to certain subtypes of prostate cancer. The most notable finding in 2007 is the highly reproducible link between the chromosome 8q24 risk region and prostate cancer susceptibility.Summary Besides the link between the 8q24 region and prostate cancer risk, population studies do not convincingly show that polymorphisms in androgen metabolism genes are associated with prostate cancer risk. Large epidemiologic studies with comprehensive gene coverage and reliable exposure data are needed to clarify further the role of androgens and their related genes in prostate cancer.