CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326
CircPUM1 promotes the malignant behavior of lung adenocarcinoma by regulating miR-326
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CircPUM1通过调控miR-326促进肺腺癌恶性行为
DOI：
10.1016/j.bbrc.2018.11.176
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发表时间：
2019-01-15
影响因子：
3.1
通讯作者：
Shang, Hong
中科院分区：
文献类型：
--
作者：
Chen, Jingjing;Xu, Shun;Shang, Hong
据报道，CircRNA与肺癌的发展有关。本研究旨在探讨circumstance 1在肺腺癌中的表达、功能及其分子机制。在这里，它表明，circumstance 1在肺腺癌细胞系和组织中均显著上调。此外，circumstance 1的沉默降低了A549细胞的增殖、迁移和侵袭能力，并增加了凋亡。然而，在SPC-A1细胞中过表达circulatory 1具有相反的效果。沉默circumstance 1基因抑制裸鼠肿瘤发生。在机制上，circumstances 1可以海绵miR-326，并促进其下游蛋白Cyclin D1和Bcl-2的表达。综上所述，本研究揭示了circumstances 1作为癌基因通过circumstances 1/miR-326/Cyclin D1和Bcl-2轴促进肺腺癌的发生。这表明circumstance 1可能作为肺腺癌的潜在治疗靶点。(C)2018爱思唯尔公司All rights reserved.
CircRNAs are reported to be implicated in the development of lung cancer. This study focused on assessing the expression, functions and molecular mechanism of circPUM1 in lung adenocarcinoma. Here, it showed that circPUM1 is significantly upregulated in both lung adenocarcinoma cell lines and tissues. Furthermore, silencing of circPUM1 impaired the proliferation, migration and invasion ability, and increased apoptosis in A549 cells. Nevertheless, overexpression of circPUM1 in SPC-A1 cells has the opposite effect. Silencing of circPUM1 inhibits the tumorigenesis in nude mice. Mechanistically, circPUM1 could sponge miR-326 and promote the expression of its downstream proteins Cyclin D1 and Bcl-2. In summary, this present study revealed that circPUM1 functions as an oncogene to promote the tumorigenesis of lung adenocarcinoma through circPUM1/miR-326/Cyclin D1 and Bcl-2 axis. This indicates that circPUM1 may act as a potential therapeutic target for lung adenocarcinoma. (C) 2018 Elsevier Inc. All rights reserved.