Regulation of the Autonomic Nervous System on Intestine.

Regulation of the Autonomic Nervous System on Intestine.
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自主神经系统对肠道的调节

DOI:
10.3389/fphys.2021.700129
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发表时间:
2021
影响因子:
4
通讯作者:
Shao L
Shao L
中科院分区:
医学2区
文献类型:
--
作者:
Duan H;Cai X;Luan Y;Yang S;Yang J;Dong H;Zeng H;Shao L

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肠道由吸收上皮细胞、杯状细胞、内分泌细胞、潘氏细胞、免疫细胞等多种类型的细胞组成,发挥消化、吸收、神经内分泌、免疫等功能。肠由外源性自主神经和内源性肠神经支配。神经递质和相应受体广泛分布于不同的肠细胞中。肠道自主神经系统包括交感神经系统和副交感神经系统,在生理和病理生理条件下调节肠道细胞的增殖和功能。现就肠内植物神经系统的分布及功能特点作一综述。并对自主神经系统如何调节肠细胞增殖进行了讨论。本文就植物神经系统在肠道疾病中的作用作一综述。在治疗各种肠道疾病时,适当地操作自主神经系统可能会有所帮助。
Intestine is composed of various types of cells including absorptive epithelial cells, goblet cells, endocrine cells, Paneth cells, immunological cells, and so on, which play digestion, absorption, neuroendocrine, immunological function. Intestine is innervated with extrinsic autonomic nerves and intrinsic enteric nerves. The neurotransmitters and counterpart receptors are widely distributed in the different intestinal cells. Intestinal autonomic nerve system includes sympathetic and parasympathetic nervous systems, which regulate cellular proliferation and function in intestine under physiological and pathophysiological conditions. Presently, distribution and functional characteristics of autonomic nervous system in intestine were reviewed. How autonomic nervous system regulates intestinal cell proliferation was discussed. Function of autonomic nervous system on intestinal diseases was extensively reviewed. It might be helpful to properly manipulate autonomic nervous system during treating different intestinal diseases.
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