Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain
Parvalbumin-immunoreactive neurons in the hippocampal formation of Alzheimer's diseased brain
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DOI：
10.1016/s0306-4522(97)00068-7
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发表时间：
1997-10-01
期刊：
影响因子：
3.3
通讯作者：
Mufson, EJ
中科院分区：
文献类型：
--
作者：
Brady, DR;Mufson, EJ
用免疫细胞化学染色法测定了对照和阿尔茨海默病脑海马组织中小白蛋白中间神经元的数量和分布。在对照海马，小白蛋白中间神经元呈多形突起，具有广泛的树突状乔木。在齿状回，小蛋白细胞以及密集的纤维丛和小点与颗粒细胞相关。少数细胞也占据了分子层。在CA1-CA3亚区向东层和锥体层中，小蛋白神经元产生树突，树突延伸至邻近层。在金字塔状地层中，斑点和珠状纤维染色较密，在邻近的东方和辐射状地层中染色较少。在腔隙层-分子层或肺泡中几乎没有观察到细小蛋白的分布。大量的多形性小蛋白神经元和密集的纤维丛和小点是下带深层和下带前外主板的特征。在阿尔茨海默病海马中，齿状回/CA4亚区小白蛋白中间神经元数量减少约60% (P
The number and topographic distribution of immunocytochemically stained parvalbumin interneurons was determined in the hippocampal formation of control and Alzheimer's diseased brain. In control hippocampus, parvalbumin interneurons were aspiny and pleomorphic, with extensive dendritic arbors. In dentate gyrus, parvalbumin cells, as well as a dense plexus of fibers and puncta, were associated with the granule cell laver. A few cells also occupied the molecular layer. In strata oriens and pyramidale of CA1-CA3 subfields, parvalbumin neurons gave rise to dendrites that extended into adjacent strata. Densely stained puncta and beaded fibers occupied stratum pyramidale, with less dense staining in adjacent strata oriens and radiatum. Virtually no parvalbumin profiles were observed in stratum lacunosum-moleculare or the alveus. Numerous polymorphic parvalbumin neurons and a dense plexus of fibers and puncta characterized the deep layer of the subiculum and the lamina principalis externa of the presubiculum. In Alzheimer's diseased hippocampus, there was an approximate 60% : decrease in the number of parvalbumin interneurons in the dentate gyrus/CA4 subfield (P