Interaction of monofluorophosphate with plaque and saliva.
Interaction of monofluorophosphate with plaque and saliva.
复制标题
单氟磷酸盐与牙菌斑和唾液的相互作用。
DOI：
10.1159/000260731
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发表时间：
1983
期刊：
影响因子：
4.2
通讯作者：
Rølla,G
中科院分区：
文献类型：
--
作者：
Rølla,G
大多数单氟磷酸盐 (MFP) 的防龋作用机制都是基于体外模型研究的观察结果。最近的研究结果表明，与在无牙菌斑区域使用相同制剂时相比，使用 MFP 时，牙菌斑下方的牙釉质中会发现更多的氟化物。实验描述表明，MFP 在从牙齿上解吸吸附的白蛋白方面比正磷酸盐更有效。临床实验表明，每两周在未去除牙菌斑的牙齿上局部使用 MFP 可有效减少蛀牙。 MFP 溶液中存在月桂基硫酸盐会降低该方法的临床疗效。这表明，斑块中存在十二烷基硫酸盐时，酶活性降低，导致 MFP 中 F- 的释放减少，这一事实可能是防龋活性降低的原因。结论是体外模型可能与临床防龋无关。单氟磷酸盐（MFP）的防龋作用的建议机制几乎完全基于体外模型研究。因此，关于所建议机制的相对优点的讨论必须集中于这些体外模型如何与作为临床现象的龋齿抑制相关。众所周知，没有可靠的体外模型可以预测含氟离子制剂的临床效果[Gron，1977]，同样的结论也适用于MFP。而MFP和F"的临床效果处于同一数量级
Most suggested mechanisms for the cariostatic effect of monofluorophosphate (MFP) are based on observations from in vitro model studies. Recent findings suggest that more fluoride can be found in enamel underneath plaque when MFP has been applied than when the same preparation was applied in plaque-free areas. Experiments are described which show that MFP is more effective than orthophosphate in desorbing adsorbed albumin from teeth. Clinical experiments indicated that topical application of MFP to teeth without plaque removal on a biweekly basis was effective in reducing decay. Presence of lauryl sulfate in the MFP solutions reduced the clinical efficacy of the approach. This suggests that reduced enzymatic activity in the presence of lauryl sulfate in plaque causes reduced liberн ation ofF-from MFP and this fact may account for the reduced cariostatic activity. The conclusion is made that in vitro models are probably not relevant to clinical caries inhibiн tion.The suggested mechanisms of the carioн static effect of monofluorophosphate (MFP) are based almost exclusively on in vitro model studies. A discussion concerning the relative merits of the suggested mechanisms will thus have to concentrate on how these in vitro models relate to caries inhibition as a clinical phenomenon. It is generally known that no reliable in vitro model is available where the clinical effect of preparations conн taining fluoride ions can be predicted [Gron, 1977], The same conclusion is valid also for MFP. Whereas the clinical effect of MFP and F" is in the same order of magnitude