The importance of interstitial cells of cajal in the gastrointestinal tract.
The importance of interstitial cells of cajal in the gastrointestinal tract.
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DOI：
10.4103/1319-3767.105909
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发表时间：
2013-01
期刊：
影响因子：
--
通讯作者：
Al-Shboul OA
中科院分区：
文献类型：
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作者：
Al-Shboul OA
胃肠道 (GI) 运动功能及其调节是一个复杂的过程，涉及多种细胞类型的协作和通信，例如肠神经元、卡哈尔间质细胞 (ICC) 和平滑肌细胞。胃肠道研究的最新进展使人们更好地了解了 ICC 的功能及其在胃肠道中的作用，基于不同类型技术的研究表明 ICC 作为胃肠道神经肌肉装置的组成部分，可以传导肠运动神经元的输入，在相位平滑肌中产生内在的电节律性，并具有机械感觉能力。这些细胞的缺失或功能不正常与一些胃肠道疾病有关。本文提供了 ICC 的总体概述；它们的发现、亚型、功能、在胃肠道中的位置以及与它们的丢失或疾病相关的一些疾病，并强调了关于 ICC 在胃肠道中的重要性的一些有争议的问题。
Gastrointestinal (GI) motility function and its regulation is a complex process involving collaboration and communication of multiple cell types such as enteric neurons, interstitial cells of Cajal (ICC), and smooth muscle cells. Recent advances in GI research made a better understanding of ICC function and their role in the GI tract, and studies based on different types of techniques have shown that ICC, as an integral part of the GI neuromuscular apparatus, transduce inputs from enteric motor neurons, generate intrinsic electrical rhythmicity in phasic smooth muscles, and have a mechanical sensation ability. Absence or improper function of these cells has been linked to some GI tract disorders. This paper provides a general overview of ICC; their discovery, subtypes, function, locations in the GI tract, and some disorders associated with their loss or disease, and highlights some controversial issues with regard to the importance of ICC in the GI tract.