Association of angiotensin‐converting‐enzyme gene polymorphism with the depressor response to mild exercise therapy in patients with mild to moderate essential hypertension
Association of angiotensin‐converting‐enzyme gene polymorphism with the depressor response to mild exercise therapy in patients with mild to moderate essential hypertension
复制标题
血管紧张素转换酶基因多态性与轻中度原发性高血压患者轻度运动治疗的降压反应的关系
作者：
Bo Zhang;T. Sakai;Shin;A. Kiyonaga;Hiroaki Tanaka;M. Shindo;K. Saku
本文研究了日本轻中度高血压患者血管紧张素转换酶基因多态性与运动降压反应的关系。每个受试者在自行车测功器上进行10 周的轻度(乳酸阈值强度：大约50%最大耗氧量)运动治疗。运动疗法可显著降低ACE-II和ID等位基因携带者的收缩压(SPB)、舒张压(DPB)和平均动脉压(MAP)，但对DD携带者无明显影响。DBP和MAP的时间-基因互作效应显著。多元Logistic回归分析显示，D等位基因缺乏降压反应的年龄和基线血浆肾素活性调整的相对危险度(OR值)为2.72[95%可信区间(CI)1.07~6.91；p = 0.034]；DD型与DI和II型(假设D等位基因为隐性)相比，OR值为11.7(95%CI，2.25~60.6；p = 0.003)。ACE基因I/D多态性与高血压患者对轻度运动治疗的降压反应有关，这表明至少部分遗传特征可能是高血压患者对轻度运动治疗的降压反应异质性的基础。
We studied the association of angiotensin I‐converting enzyme (ACE) gene polymorphism with the depressor response to exercise therapy in 64 Japanese subjects with mild to moderate essential hypertension. Each subject performed 10 weeks of mild (lactate threshold intensity: approximately 50% maximum oxygen consumption) exercise therapy on a bicycle ergometer. Systolic blood pressure (SPB), diastolic blood pressure (DPB), and mean arterial pressure (MAP) were significantly decreased by exercise therapy in subjects with the ACE‐II and ID genotypes but not in DD subjects. The time‐by‐genotype interaction effects were significant for DBP and MAP. According to a multiple logistic regression analysis, the age‐ and baseline plasma renin activity‐adjusted relative risk (odds ratio) for the lack of a depressor response conferred by the D allele (assuming an additive effect) was 2.72 [95% confidence interval (CI), 1.07–6.91; p = 0.034]; for DD genotypes, as compared with the DI and II genotypes (assuming that the D allele is recessive), it was 11.7 (95% CI, 2.25–60.6; p = 0.003). ACE gene I/D polymorphism is associated with the depressor response of essential hypertensives to mild exercise therapy, which suggests that genetic features may underlie, at least in part, the heterogeneity of the depressor response in essential hypertensives to mild exercise therapy.
影响因子：
9.8
作者：
L. Tiret;B. Rigat;S. Visvikis;C. Breda;P. Corvol;F. Cambien;F. Soubrier
通讯作者：
L. Tiret;B. Rigat;S. Visvikis;C. Breda;P. Corvol;F. Cambien;F. Soubrier