Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome.
Normal cerebrospinal fluid levels of hypocretin-1 (orexin A) in patients with fibromyalgia syndrome.
复制标题
纤维肌痛综合征患者脑脊液中下丘脑分泌素-1（食欲素 A）的正常水平。
DOI：
10.1016/j.sleep.2006.08.015
复制
发表时间：
2007
期刊：
影响因子：
4.8
通讯作者：
Larson,AliceA
中科院分区：
文献类型：
--
作者：
Taiwo,OludareB;Russell,IJon;Mignot,Emmanuel;Lin,Ling;Michalek,JoelE;Haynes,Wanda;Xiao,Yangming;Zeitzer,JamieM;Larson,AliceA
下丘脑神经肽下丘脑泌素（orexin）调节睡眠-觉醒、摄食和内分泌功能。发作性睡病-痉挛症患者脑脊液（CSF）下丘脑泌素-1（Hcrt-1）浓度较低，发作性睡病-痉挛症是一种以嗜睡和快速眼动（REM）睡眠异常为特征的睡眠障碍。失眠和在某些情况下，白天嗜睡症。TFTSBasal CSF水平的Hcrt-1在FMS中并没有不同于那些在健康的正常controls. CONCLUSION这些研究结果表明，异常低Hcrt-1是不是一个可能的原因疲劳在FMS。
BACKGROUNDThe hypothalamic neuropeptide hypocretin (orexin) modulates sleep–wake, feeding and endocrine functions. Cerebrospinal fluid (CSF) hypocretin-1 (Hcrt-1) concentrations are low in patients with narcolepsy–cataplexy, a sleep disorder characterized by hypersomnolence and rapid eye movement (REM) sleep abnormalities.METHODSWe determined CSF Hcrt-1 concentrations of patients with the fibromyalgia syndrome (FMS), a condition characterized by fatigue, insomnia and in some cases daytime hypersomnolence.RESULTSBasal CSF levels of Hcrt-1 in FMS did not differ from those in healthy normal controls.CONCLUSIONSThese findings suggest that abnormally low Hcrt-1 is not a likely cause of fatigue in FMS.