Expansion of afferent vestibular signals after the section of one of the vestibular nerve branches
Expansion of afferent vestibular signals after the section of one of the vestibular nerve branches
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DOI：
10.1152/jn.2000.84.1.581
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发表时间：
2000-07-01
影响因子：
2.5
通讯作者：
Dieringer, N
中科院分区：
文献类型：
--
作者：
Goto, F;Straka, H;Dieringer, N
N.前分支。八是在成年青蛙切片。两个月后，分离大脑，记录电刺激N前分支后前庭核和外展神经的体外反应。或后管神经。将完整侧和手术侧的细胞外和细胞内记录的反应与对照组的反应进行比较。主要变化检测到的手术侧：后管神经诱发场电位的幅度扩大，前庭神经元的数量增加，从后管神经的单突触输入，和后管神经刺激招募更强的外展神经反应的完整侧比反之亦然。前庭神经传入输入的会聚模式的变化，在手术侧强烈建议的扩展后通道相关的传入输入到部分的前庭神经元，被剥夺了他们的传入前庭输入。作为一种机制，我们建议反应性突触之间的完整的后管传入纤维和前庭剥夺二级前庭神经元。
The anterior branch of N. VIII was sectioned in adult frogs. Two months later the brain was isolated to record in vitro responses in the vestibular nuclei and from the abducens nerves following electric stimulation of the anterior branch of N. VIII or of the posterior canal nerve. Extra- and intracellularly recorded responses from the intact and operated side were compared with responses from controls. Major changes were detected on the operated side: the amplitudes of posterior canal nerve evoked field potentials were enlarged, the number of vestibular neurons with a monosynaptic input from the posterior canal nerve had increased, and posterior canal nerve stimulation recruited stronger abducens nerve responses on the intact side than vice versa. Changes in the convergence pattern of vestibular nerve afferent inputs on the operated side strongly suggest the expansion of posterior canal-related afferent inputs onto part of those vestibular neurons that were deprived of their afferent vestibular input. As a mechanism we suggest reactive synaptogenesis between intact posterior canal afferent fibers and vestibularly deprived second-order vestibular neurons.