Central vasopressin system mediation of acute pressor effect of gamma-MSH.
Central vasopressin system mediation of acute pressor effect of gamma-MSH.
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中枢加压素系统介导γ-MSH 的急性升压作用。
DOI：
10.1152/ajpendo.1986.251.1.e134
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发表时间：
1986
期刊：
影响因子：
--
通讯作者：
Eskridge,SL
中科院分区：
文献类型：
--
作者：
Gruber,KA;Eskridge,SL
静脉内（iv）给予γ-黑素细胞刺激激素（γ-MSH）可产生中枢交感神经介导的升压和心脏加速效应，并增加下丘脑加压素能神经元的活性。其自主活动类似于将加压素（Vp）注入第四脑室（Ven）后脑。为了确定中枢Vp系统的激活是否是γ-MSH升压效应的近因，我们研究了γ-MSH对中枢神经系统Vp受体阻断前后大鼠和遗传性加压素缺乏大鼠（Brattleboro品系）的影响。阻断中枢Vp受体可显著降低（80%）iv γ-MSH的升压作用。作为对照，静脉注射拮抗剂，而有效地阻断静脉Vp的升压作用，对γ-MSH升压反应没有影响。当与它们的遗传对照（Long-Evans品系）相比时，Brattleboro大鼠对iv γ-MSH的升压反应也降低了80%以上。结果表明，循环γ-MSH激活中枢Vp系统，产生其交感兴奋性升压效应。
Intravenous (iv) administration of gamma-melanocyte-stimulating hormone (gamma-MSH) produces central sympathetically mediated pressor and cardioaccelerator effects and increases the activity of hypothalamic vasopressinergic neurons. The autonomic actions are similar to infusion of vasopressin (Vp) into the hindbrain of 4th ventricle (Ven). To ascertain whether activation of the central Vp system is the proximate cause of the pressor effects of gamma-MSH, we investigated the effects of gamma-MSH in rats pre- and postblockade of central nervous system Vp receptors and in rats with a hereditary lack of vasopressin (Brattleboro strain). Central Vp receptor blockade significantly reduced (80%) the pressor effects of iv gamma-MSH. As a control, iv administration of the antagonist, while effective in blocking the pressor effect of iv Vp, had no effect on the gamma-MSH pressor response. When compared with their genetic controls (Long-Evans strain), Brattleboro rats also had greater than 80% reduction in their pressor response to iv gamma-MSH. The results indicate that circulating gamma-MSH activates the central Vp system to produce its sympathoexcitatory pressor effects.