Neural correlates of social well-being: gray matter density in the orbitofrontal cortex predicts social well-being in emerging adulthood
Neural correlates of social well-being: gray matter density in the orbitofrontal cortex predicts social well-being in emerging adulthood
复制标题
社会福祉的神经相关性：眶额皮质灰质密度可预测成年初期的社会福祉
DOI：
10.1093/scan/nsz008
复制
发表时间：
2019-03-01
影响因子：
4.2
通讯作者：
Zhao, Jingjing
中科院分区：
文献类型：
--
作者：
Kong, Feng;Yang, Kairong;Zhao, Jingjing
社会福祉反映了人们对社会功能的看法，这在身体和心理健康中起着重要作用。但是，社会福祉的确切神经解剖基板尚不清楚。为了解决这个问题，我们采用了基于体素的形态计量法来探测年轻健康成年人社会福祉中个体变化的神经解剖学基础（n = 136）。结果表明，社会健康与区域灰质密度（RGMD）之间存在显着的负面关联，该群集主要包括参与情绪调节和社会认知的左眶额皮质（OFC）。此外，使用机器学习方法平衡的4倍交叉验证表明，左OFC中的RGMD可能与社会福祉可靠地相关。更重要的是，多重调解分析表明，神经质和性格宽恕独立地介导了RGMD在左OFC与社会福祉之间的关联。此外，当控制主观的社会经济地位时，所有这些结果保持稳定。总之，我们的结果提供了最初的证据，即OFC是社会福祉的神经解剖基底物，并证明OFC是一个关键的神经部位，将神经质和性格宽恕与社会福祉联系起来。
Social well-being reflects the perception of one's social functioning, which plays an important role in physical and psychological health. However, the exact neuroanatomical substrate for social well-being remains unclear. To address the issue, we employed the voxel-based morphometry method to probe the neuroanatomical basis of individual variation in social well-being in young healthy adults (n=136). The results revealed a significant negative association between social well-being and regional gray matter density (rGMD) in an anatomical cluster that mainly includes the left orbitofrontal cortex (OFC) that has been involved in emotion regulation and social cognition. Furthermore, a balanced 4-fold cross-validation using the machine learning approach revealed that rGMD in the left OFC could be reliably related to social well-being. More importantly, the multiple mediation analysis revealed that neuroticism and dispositional forgiveness independently mediated the association between rGMD in the left OFC and social well-being. In addition, all these results remained stable when subjective socioeconomic status was controlled. Together, our results provide the initial evidence that the OFC is a neuroanatomical substrate for social well-being and demonstrate that the OFC is a crucial neural site linking neuroticism and dispositional forgiveness to social well-being.