The relative effects of arterial curvature and lumen diameter on wall shear stress distributions in human right coronary arteries
The relative effects of arterial curvature and lumen diameter on wall shear stress distributions in human right coronary arteries
复制标题
动脉曲率和管腔直径对人右冠状动脉壁剪应力分布的相对影响
DOI：
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发表时间：
2007
影响因子：
3.5
通讯作者：
P. Johnston
中科院分区：
文献类型：
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作者：
B. Johnston;P. Johnston
这项研究着眼于四种不同的人类右冠状动脉 (RCA) 的血流，这些动脉是根据双平面血管造影重建的。血液粘度的广义幂律模型用于研究心动周期中特定点的血流量。四个动脉的壁剪切应力大小（WSS）分布存在很大差异，因此得出的结论是不可能根据单个动脉的研究进行概括。研究发现，WSS 的模式与特定动脉的几何形状有关，即管腔直径和动脉曲率以及这两个因素的组合。 WSS 和倒数半径之间存在很强的相关性，而高曲率和 WSS 极端值之间的相关性较弱，即弯道“内侧”的 WSS 较高，而弯道“外侧”的 WSS 较低。这与具有恒定半径的简单弯曲管的情况相反，在该情况下观察到相反情况。对于每条动脉，识别出靠近急性边缘的区域，在该区域中发现 WSS 较低，并且 RCA“内”壁上的 WSS 低于“外”壁上的 WSS。多项研究发现，人类 RCA 优先在该区域出现动脉粥样硬化形成。
This study looks at blood flow in four different human right coronary arteries (RCAs), which have been reconstructed from bi-plane angiograms. A generalized power-law model of blood viscosity is used to study the blood flow at a particular point in the cardiac cycle. Large differences are found in the wall shear stress magnitude (WSS) distributions in the four arteries, leading to the conclusion that it is not possible to make generalizations based on the study of a single artery. The pattern of WSS is found to be related to the geometry of a particular artery, that is, lumen diameter and arterial curvature as well as a combination of these two factors. There is a strong correlation between WSS and reciprocal radius and a weaker correlation between high curvature and extremes of WSS, with high WSS on the ‘inside’ of a bend and low WSS on the ‘outside’ of a bend. This is in contrast to the situation for a simple curved tube with constant radius where the inverse is observed. For each artery, a region proximal to the acute margin is identified where low WSS is found and where WSS is lower on the ‘inner’ wall of the RCA than on the ‘outer’ wall. This region is one where several studies have found that the human RCA preferentially exhibits atherogenesis.
DOI：
10.1115/1.2891384
发表时间：
1992-08-01
影响因子：
1.7
作者：
NEREM, RM
通讯作者：
NEREM, RM
影响因子：
20.1
作者：
ASAKURA, T;KARINO, T
通讯作者：
KARINO, T