Bone Morphogenetic Protein 2 (BMP2) may Contribute to Partition of Energy Storage into Visceral and Subcutaneous Fat Depots
Bone Morphogenetic Protein 2 (BMP2) may Contribute to Partition of Energy Storage into Visceral and Subcutaneous Fat Depots
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DOI：
10.1002/oby.21571
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发表时间：
2016-10-01
期刊：
影响因子：
6.9
通讯作者：
Blueher, Matthias
中科院分区：
文献类型：
--
作者：
Guiu-Jurado, Esther;Unthan, Mark;Blueher, Matthias
目的：骨形态发生蛋白（BMPs）是脂肪形成的重要调节因子，可能在肥胖中起重要作用。本研究验证了BMP2与肥胖中脂肪组织（AT）分布有关的假设。方法：测定547例不同体重指数个体的内脏和皮下AT配对样本中BMP2血清浓度（n = 439）和BMP2、Schnurri-1和22 mRNA的表达。此外，对631例个体的BMP2基因的单核苷酸多态性rs979012进行了基因分型，用于随后的肥胖相关数量性状的关联研究。结果：与皮下AT相比，内脏AT中BMP2和Schnurri-1 mRNA明显升高。与健康和苗条的人相比，肥胖人群中两个仓库的BMP2表达明显更高。伴有中度但非病态肥胖的2型糖尿病患者血清BMP2浓度明显升高。Schnurri-1和22 mRNA的表达与BMP2表达或循环BMP2无关。最后，rs979012显示出与身体质量指数和总胆固醇水平的名义关联。结论：数据表明，随着储存过多能量的需求增加，AT BMP2表达增加，可能有助于将能量储存分配到内脏和皮下AT库。
Objective: Bone morphogenetic proteins (BMPs) are important regulators of adipogenesis and may play a role in obesity. In this study, the hypothesis that BMP2 is related to adipose tissue (AT) distribution in obesity was tested.Methods: BMP2 serum concentration (n = 439) and BMP2 and Schnurri-1 and 22 mRNA expression were measured in paired samples of visceral and subcutaneous AT from 547 individuals with a wide range of body mass index. In addition, a single nucleotide polymorphism rs979012 in the BMP2 gene was genotyped for subsequent association studies on quantitative traits related to obesity in 631 individuals.Results: BMP2 and Schnurri-1 mRNA were significantly higher in visceral compared with subcutaneous AT. Compared with individuals who were healthy and lean, BMP2 expression in both depots was significantly higher in people with obesity. Significantly higher BMP2 serum concentrations were found in patients with type 2 diabetes with moderate but not morbid obesity. Schnurri-1 and 22 mRNA expression was not related to either BMP2 expression or circulating BMP2. Finally, rs979012 showed nominal association with body mass index and total cholesterol levels.Conclusions: Data suggest that with increasing demand to store excessive energy, AT BMP2 expression increases and may contribute to partitioning of energy storage into visceral and subcutaneous AT depots.