The REEP family of proteins: Molecular targets and role in pathophysiology
The REEP family of proteins: Molecular targets and role in pathophysiology
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DOI：
10.1016/j.phrs.2022.106477
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发表时间：
2022-10-13
影响因子：
9.3
通讯作者：
Li, Lanfang
中科院分区：
文献类型：
--
作者：
Fan, Sisi;Liu, Huimei;Li, Lanfang
受体表达增强蛋白（REEPs）是一个进化上保守的蛋白家族，对内质网（ER）的结构和功能至关重要。REEP家族在高等物种中可分为两大亚科，分别为REEP1-4和REEP5-6亚科。在REEP1-4亚家族中，REEP1与REEP2亲缘关系密切，REEP3与REEP4亲缘关系相似。REEP家族广泛分布于各种组织中。最近的研究表明，REEP家族参与许多病理生理过程，如内质网形态发生和重塑、微管细胞骨架调节、G蛋白偶联受体（gpcr）的转运和表达。此外，REEP家族在许多疾病的发生和发展中起着至关重要的作用，包括神经系统疾病、糖尿病、视网膜疾病、心脏病、不孕症、肥胖、少关节幼年特发性关节炎（OJIA）、COVID-19和癌症。本文综述了REEP家族的分布和结构。并对该家族的功能及相关疾病作一综述。基于REEP家族的多效性，对其家族成员的研究对于了解相关的病理生理过程和制定调节和控制这些相关疾病的策略至关重要。
Receptor expression-enhancing proteins (REEPs) are an evolutionarily conserved protein family that is pivotal to the structure and function of the endoplasmic reticulum (ER). The REEP family can be classified into two major subfamilies in higher species, the REEP1-4 and REEP5-6 subfamilies. Within the REEP1-4 subfamily, REEP1 and REEP2 are closely related, and REEP3 and REEP4 are similarly related. The REEP family is widely distributed in various tissues. Recent studies indicate that the REEP family is involved in many pathological and physiological processes, such as ER morphogenesis and remodeling, microtubule cytoskeleton regulation, and the trafficking and expression of G protein-coupled receptors (GPCRs). Moreover, the REEP family plays crucial roles in the occurrence and development of many diseases, including neurological diseases, diabetes, retinal diseases, cardiac diseases, infertility, obesity, oligoarticular juvenile idiopathic arthritis (OJIA), COVID-19, and cancer. In the present review, we describe the distribution and structure of the REEP family. Furthermore, we summarize the functions and the associated diseases of this family. Based on the pleiotropic actions of the REEP family, the study of its family members is crucial to understanding the relevant pathophysiological processes and developing strategies to modulate and control these related diseases.