Atrial natriuretic hormone and aldosterone regulation in salt-depleted state.
Atrial natriuretic hormone and aldosterone regulation in salt-depleted state.
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低盐状态下心房钠尿激素和醛固酮的调节。
DOI：
10.1152/ajpendo.1989.257.4.e583
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发表时间：
1989
期刊：
影响因子：
--
通讯作者：
Shenker,Y
中科院分区：
文献类型：
--
作者：
Shenker,Y
为了评价极低剂量心钠素（ANH）输注对醛固酮调节的影响，7名正常青年男性接受了0.47 pmol.kg-1.min-1人[Ser-Tyr 28]ANH或安慰剂输注2.5 h。在最后0.5小时内，还输注了4 pmol.kg-1.min-1的血管紧张素II。ANH血浆水平从3.46 +/- 0.25增加到最大值6.80 +/- 0.88 pmol/l，这完全在正常范围内。2小时后，血浆醛固酮下降近40%，从40.7 +/- 5.7降至25.9 +/- 4.9 ng/dl。ANH输注引起血压轻微下降，肾脏钠和钾排泄轻微增加。这些结果表明，即使ANH水平在正常范围内的微小变化，也具有生理意义，特别是在醛固酮调节中。
To evaluate the effect of very low-dose infusion of atrial natriuretic hormone (ANH) on aldosterone regulation, seven normal young men were infused for 2.5 h with 0.47 pmol.kg-1.min-1 of human [Ser-Tyr28]ANH or placebo. During the last 0.5 h 4 pmol.kg-1.min-1 of angiotensin II were also infused. ANH plasma levels increased from 3.46 +/- 0.25 to a maximum of 6.80 +/- 0.88 pmol/l, which is well within normal limits. Plasma aldosterone decreased almost 40%, from 40.7 +/- 5.7 to 25.9 +/- 4.9 ng/dl after 2 h. ANH infusion caused a slight decrease in blood pressure and slight increase in renal excretion of sodium and potassium. These results suggest that even small changes in ANH levels, within the normal range, have physiological significance, particularly in aldosterone regulation.