Risk factors for hepatic veno-occlusive disease after high-dose busulfan-containing regimens followed by autologous bone marrow transplantation: a study in 136 children.
Risk factors for hepatic veno-occlusive disease after high-dose busulfan-containing regimens followed by autologous bone marrow transplantation: a study in 136 children.
复制标题
高剂量含白消安治疗方案随后进行自体骨髓移植后发生肝静脉闭塞性疾病的危险因素：一项针对 136 名儿童的研究。
DOI：
--
复制
发表时间：
1992
影响因子：
4.8
通讯作者：
J. Lemerle
中科院分区：
文献类型：
--
作者：
V. Méresse;Olivier Hartmann;Gilles Vassal;E. Benhamou;D. Valteau‐Couanet;Laurence Brugières;J. Lemerle
对136例自体移植儿童进行了肝静脉闭塞病（HVOD）的危险因素分析，这些儿童接受了大剂量布硫丹（BU）作为调节方案的一部分。HVOD的诊断符合麦当劳的临床标准。与其他治疗方案相比，HVOD的发生率特别高（22%），但26例患者（87%）的结果是有利的。发生4例死亡（13%），其中1例与HVOD有关。HVOD的临床表现与以往报道相似。虽然统计分析未能证明任何预测结果的因素，但它确实确定了HVOD发生的危险因素：这些因素是(1)布鲁里溃疡总剂量超过标准16 mg/kg剂量；(2)使用三种而不是两种烷基化剂；(3)在含有三种烷基化剂的调理方案中给予BU给药的顺序；(4)联合酮康唑治疗。
Risk factors for hepatic veno-occlusive disease (HVOD) were analysed in a population of 136 autografted children who received high-dose busulfan (BU) as part of a conditioning regimen. HVOD was diagnosed according to McDonald's clinical criteria. The incidence of HVOD was particularly high in this series (22%) compared with series with other conditioning regimens but the outcome was favorable in 26 patients (87%). Four deaths occurred (13%), one of which was HVOD related. The clinical presentation of HVOD was similar to that described in previous reports. Although statistical analysis failed to demonstrate any factors predictive of outcome, it did identify risk factors for the occurrence of HVOD: these were (1) a total dose of BU exceeding the standard 16 mg/kg dose; (2) the use of three as opposed to two alkylating agents; (3) the sequence of BU administration when given in the conditioning regimen containing three alkylating agents; and (4) concomitant ketoconazole therapy.