ISOLATION AND IDENTIFICATION OF A CANNABINOID-LIKE COMPOUND FROM AMORPHA SPECIES
ISOLATION AND IDENTIFICATION OF A CANNABINOID-LIKE COMPOUND FROM AMORPHA SPECIES
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DOI：
10.1021/np50005a004
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发表时间：
1979-01-01
影响因子：
5.1
通讯作者：
WOOLSEY, NF
中科院分区：
文献类型：
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作者：
KEMAL, M;KHALIL, SKW;WOOLSEY, NF
以耐晒蓝B盐为显色剂，在薄层板上对几种植物的石油醚提取物进行了筛选。不同植物部位的提取物具有与大麻提取物相似的色泽和Rf值。用柱层析法分离得到主要化合物，用熔点、元素分析、UV、IR、MS、PMR和CMR谱对其进行了纯化和表征。通过分析该化合物的氧化产物，获得了进一步的信息。有证据表明，非晶是一种苯二烯萜类化合物，分子式为C24H28O2，结构式为(E，E)-2-(3‘’，7‘’-dimethyl-2‘’，6‘’-octadienyl)-5-(2-phenylethenyl)-1，3-benzenediol.这是首次分离到具有萜类结构的天然二苯乙烯类化合物。
The petroleum ether extracts from several plants were screened on TLC plates with the chromogenic reagent Fast Blue B. salt. Extracts from different plant parts of A. fruticosa, A. nanna and A. canescens gave several spots with color and Rf values similar to those of Cannabis sativa extract. The major compound, amorphastilbol, was isolated by column chromatography, purified and characterized by melting point, elemental analysis, UV, IR, MASS, PMR and CMR [carbon magnetic resonance] spectroscopy. Further information was obtained by analyzing the oxidation products of the compound. Evidence indicates that amorphastilbol is a phenolic stilbene terpenoid with a molecular formula of C24H28O2 and structural formula of (E,E)-2-(3'',7''-dimethyl-2'',6''-octadienyl)-5-(2-phenylethenyl)-1,3-benzenediol. This is the 1st report of the isolation of a naturally-occurring stilbene derivative possessing a terpenoid moiety.